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Environmentally-friendly reduced graphene oxide functionalized with hyaluronic acid for targeted cancer photothermal therapy

2019-10-23Conference object Open access
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dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorAlves, Cátia
dc.contributor.authorCosta, Elisabete
dc.contributor.authorFerreira, Paula
dc.contributor.authorLouro, Ricardo
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-01-10T10:22:31Z
dc.date.available2020-01-10T10:22:31Z
dc.date.issued2019-10-23
dc.description.abstractReduced Graphene Oxide (rGO) is one of the most promising nanomaterials for cancer photothermal therapy (PTT) due to its high near infrared (NIR) absorption. However, the rGO producing methods uses dangerous reducing agents, resulting in poor biocompatibility. Additionally, rGO also displays poor colloidal stability and is unable to target cancer cells. These limitations can be improved by using environmentally-friendly reduction methods and by functionalizing this nanomaterial with amphiphilic polymers. In this work, the production of reduced Graphene Oxide (rGO) rGO was performed by using an environmentally-friendly method (reduction with L-ascorbic Acid (LAA)). Then, the obtained rGO was functionalized with an amphiphilic polymer based on hyaluronic acid (HA-g-PMAO) for application in CD44-targeted breast cancer PTTpt_PT
dc.description.sponsorshipGrants UBI/Santander-Tottapt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8191
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectReduced graphene oxidept_PT
dc.subjectCancerpt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectHyaluronic acidpt_PT
dc.titleEnvironmentally-friendly reduced graphene oxide functionalized with hyaluronic acid for targeted cancer photothermal therapypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.conferencePlaceLisboapt_PT
oaire.citation.titleEuropean Graphene Forum 2019pt_PT
oaire.fundingStream5876
person.familyNameSousa
person.familyNameMiguel de Melo Diogo
person.familyNameAlves
person.familyNameda Rocha Costa
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameLouro
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.givenNameAna Rita Lima
person.givenNameDuarte
person.givenNameCátia Gomes
person.givenNameElisabete Cristina
person.givenNamePaula
person.givenNameRicardo
person.givenNameAntónio
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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