Repository logo
 
Publication

Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: An in vitro study

2017-05-01Journal article Restricted access
Simple item page
dc.contributor.authorPimenta, Andreia
dc.contributor.authorVieira, Ana Paula
dc.contributor.authorColaco, Rogério
dc.contributor.authorSaramago, Benilde
dc.contributor.authorGil, Maria
dc.contributor.authorCoimbra, Patrícia
dc.contributor.authorAlves, Patrícia
dc.contributor.authorBozukova, Dimitriya
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorGuiomar, António
dc.contributor.authorSerro, A.P.
dc.date.accessioned2018-03-22T11:14:38Z
dc.date.available2018-03-22T11:14:38Z
dc.date.issued2017-05-01
dc.description.abstractIntraocular lenses (IOLs) present an alternative for extended, local drug delivery in the prevention of post-operative acute endophthalmitis. In the present work, we modified the surface of a hydrophilic acrylic material, used for manufacturing of IOLs, through plasma-assisted grafting copolymerization of 2-acrylamido-2-methylpropane sulfonic acid (AMPS) or [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), with the aim of achieving a controlled and effective drug release. The material was loaded with moxifloxacin (MFX), a commonly used antibiotic for endophthalmitis prevention. The characterization of the modified material showed that relevant properties, like swelling capacity, wettability, refractive index and transmittance, were not affected by the surface modification. Concerning the drug release profiles, the most promising result was obtained when AMPS grafting was done in the presence of MFX. This modification led to a higher amount of drug being released for a longer period of time, which is a requirement for the prevention of endophthalmitis. The material was found to be non-cytotoxic for rabbit corneal endothelial cells. In a second step, prototype IOLs were modified with AMPS and loaded with MFX as previously and, after sterilization and storage (30 days), they were tested under dynamic conditions, in a microfluidic cell with volume and renovation rate similar to the eye aqueous humour. MFX solutions collected in this assay were tested against Staphylococcus aureus and Staphylococcus epidermidis and the released antibiotic proved to be effective against both bacteria until the 12th day of release.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPimenta, A. F. R., Vieira, A. P., Colaço, R., Saramago, B., Gil, M. H., Coimbra, P., Alves, P., Bozukova, D., Correia, T. R., Correia, I. J., Guiomar, A. J. e Serro, A. P. (2017) “Controlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: An in vitro study.” Colloids and Surfaces B: Biointerfaces, Vol.156, pp.95-103pt_PT
dc.identifier.doi10.1016/j.colsurfb.2017.04.060pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4710
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSurface modifications to control drug release from therapeutic ophthalmic lenses
dc.relationStrategic Project - UI 100 - 2013-2014
dc.relationDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
dc.relationUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
dc.relationHealth Sciences Research Centre
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0927776517302576?via%3Dihub#!pt_PT
dc.subjectOcular drug deliverypt_PT
dc.subjectControlled releasept_PT
dc.subjectPlasma graftingpt_PT
dc.subjectIntraocular lensespt_PT
dc.titleControlled release of moxifloxacin from intraocular lenses modified by Ar plasma-assisted grafting with AMPS or SBMA: An in vitro studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSurface modifications to control drug release from therapeutic ophthalmic lenses
oaire.awardTitleStrategic Project - UI 100 - 2013-2014
oaire.awardTitleDEVELOPMENT OF NEW STIMULI-RESPONSIVE POLYMER-LIPOSOME COMPLEXES BY LIVING RADICAL POLYMERIZATION AND “CLICK CHEMISTRY”
oaire.awardTitleUTILIZAÇÃO DE ENXERTOS DE OSSO ALÓGENO E MATERIAIS DERIVADOS DO SEU PROCESSAMENTO NA PREPARAÇÃO DE SISTEMAS DE LIBERTAÇÃO CONTROLADA E LOCALIZADA DE ANTIBIÓTICOS PARA APLICAÇÕES EM CIRURGIA ORTOPÉDICA
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0006%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0100%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69410%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F73367%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage103pt_PT
oaire.citation.startPage95pt_PT
oaire.citation.titleColloids and Surfaces B: Biointerfacespt_PT
oaire.citation.volume156pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStream6817 - DCRRNI ID
person.familyNamePimenta
person.familyNameColaco
person.familyNameSaramago
person.familyNameGil
person.familyNameAlmeida Coimbra
person.familyNameAlves
person.familyNameBozukova
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.familyNameRebelo Ferreira Guiomar
person.familyNameValagão Amadeu do Serro
person.givenNameAndreia
person.givenNameRogério
person.givenNameBenilde
person.givenNameMaria Helena
person.givenNamePatrícia Manuela
person.givenNamePatrícia
person.givenNameDimitriya
person.givenNameTiago
person.givenNameIlídio
person.givenNameAntónio Jorge
person.givenNameAna Paula
person.identifierUMbJ1KMAAAAJ
person.identifierH-7797-2012
person.identifier.ciencia-idAE12-F979-3B19
person.identifier.ciencia-id3E1B-CD88-4E37
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.ciencia-id111E-0CE2-0C3E
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id9312-E34E-C90B
person.identifier.ciencia-idC012-F8B6-A58E
person.identifier.orcid0000-0002-9990-4581
person.identifier.orcid0000-0002-5529-1621
person.identifier.orcid0000-0002-8968-4781
person.identifier.orcid0000-0003-0657-7751
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0001-5108-4556
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-6179-9296
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id57191821317
person.identifier.scopus-author-id6701406502
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6603259828
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa2c6dfdf-ce46-46f2-8a10-234061249eda
relation.isAuthorOfPublicationac0f3c8c-a4b8-454c-b358-cd66f46f9fc3
relation.isAuthorOfPublication0ad806a9-8291-4af9-8aee-e6de6f6ea2b1
relation.isAuthorOfPublication676a8017-743a-4f22-93be-4915428f318d
relation.isAuthorOfPublication95a46930-ac14-449d-8ddd-db23927062b0
relation.isAuthorOfPublication64a3aef7-8d91-4327-8407-294909eed51a
relation.isAuthorOfPublication3a374faa-6f9e-49f2-b1bb-6af70e2cdeaf
relation.isAuthorOfPublicationafa2836e-3210-4320-9c63-0b52828e043a
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication3ef06c47-679e-4a84-9c65-25fa81ae6258
relation.isAuthorOfPublication02edea7c-61f6-4acd-9539-ac43ae44cfdf
relation.isAuthorOfPublication.latestForDiscoveryf2c3e779-34a2-4309-950a-80687664c6ad
relation.isProjectOfPublication833df203-a8ed-4efc-b505-db40c53313e1
relation.isProjectOfPublication9658f94d-49c4-4b84-bd14-a9074da3bea2
relation.isProjectOfPublication4fbaf6cc-cc34-4641-a856-9cc9793cc856
relation.isProjectOfPublication32509dd2-26d9-4c7c-ad3d-5f30dbc6124e
relation.isProjectOfPublicationeb51c023-622d-4ecf-8177-f197f71ce004
relation.isProjectOfPublication1bea56d9-b91c-42af-a6d6-8004792eaac0
relation.isProjectOfPublication.latestForDiscovery833df203-a8ed-4efc-b505-db40c53313e1

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2017 Pimenta COLSUB.pdf
Size:
2.17 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito