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Hyaluronic acid functionalized nanoparticles loaded with IR780 and DOX for cancer chemo-photothermal therapy

2019-04Journal article Restricted access
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dc.contributor.authorAlves, Cátia
dc.contributor.authorDiogo, Duarte Miguel De Melo
dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorCosta, Elisabete
dc.contributor.authorCorreia, Ilidio
dc.date.accessioned2019-03-07T16:15:27Z
dc.date.available2019-03-07T16:15:27Z
dc.date.issued2019-04
dc.description.abstractIR780 is a near infrared (NIR) dye with a huge potential to be applied in cancer phototherapy and imaging. However, IR780 poor water solubility and acute cytotoxicity limit its direct use in cancer theragnostic. Herein, a novel Hyaluronic acid (HA)-based amphiphilic polymer was used, for the first time, in the preparation of polymeric nanoparticles (HPN) encapsulating IR780 aimed to be applied in breast cancer therapy. Furthermore, HPN co-encapsulating IR780 and Doxorubicin (DOX) were also produced in order to further enhance the therapeutic effectiveness of this nanoformulation. The results revealed that HPN were able to successfully encapsulate IR780 (IR-HPN) and the IR780-DOX combination (IR/DOX-HPN). Furthermore, the encapsulation of IR780 in HPN improved its absorption at 808 nm by about 2.2-fold, thereby enhancing its photothermal potential, as well as its cytocompatibility. The 2D in vitro cell uptake studies demonstrated that the nanostructures displayed a higher internalization by breast cancer cells than by normal cells. In addition, the assays performed in 3D in vitro models of breast cancer revealed that HPN can penetrate into spheroids. Furthermore, the 3D in vitro studies also demonstrated that the combined application of IR-HPN and NIR light was unable to induce cytotoxicity on spheroids. In contrast, IR/DOX-HPN produced a decrease on spheroids cells' viability, and their combination with NIR light induced an even stronger therapeutic effect, thus revealing the potential of these nanoparticles for cancer chemo-phototherapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ejpb.2019.02.016pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6894
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectChemotherapypt_PT
dc.subjectDoxorubicinpt_PT
dc.subjectIR780pt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectPolymeric nanoparticlespt_PT
dc.titleHyaluronic acid functionalized nanoparticles loaded with IR780 and DOX for cancer chemo-photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.endPage94pt_PT
oaire.citation.startPage86pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume137pt_PT
oaire.fundingStream5876
person.familyNameAlves
person.familyNameMiguel de Melo Diogo
person.familyNameSousa
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.givenNameCátia Gomes
person.givenNameDuarte
person.givenNameAna Rita Lima
person.givenNameElisabete Cristina
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos de autor foram cedidos à editora Elsevierpt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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