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Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort

2017-04-25Journal article Open access
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dc.contributor.authorAllwood, Brian W
dc.contributor.authorGillespie, Rencia
dc.contributor.authorGalperin-Aizenberg, Maya
dc.contributor.authorBateman, Mary
dc.contributor.authorOlckers, Helena
dc.contributor.authorBarata, Luis Taborda
dc.contributor.authorCalligaro, Gregory L
dc.contributor.authorSaid-Hartley, Qonita
dc.contributor.authorVan Zyl-Smit, Richard
dc.contributor.authorCooper, Christopher B
dc.contributor.authorVan Rikxoort, Eva
dc.contributor.authorGoldin, Jonathan
dc.contributor.authorBeyers, Nulda
dc.contributor.authorBateman, Eric
dc.date.accessioned2020-02-21T10:59:48Z
dc.date.available2020-02-21T10:59:48Z
dc.date.issued2017-04-25
dc.description.abstractBackground. An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype. Objective. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB. Methods. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied. Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT scans to assess bronchial anatomy and the presence of emphysema (<–950 HU), gas trapping (<–860 HU) and fibrosis (>–200 HU). Findings in subjects with a past history and/or HRCT evidence of PTB were compared with those in subjects without these features. Results. One hundred and seven of 196 eligible subjects (54.6%) were enrolled, 104 performed physiology tests and 94 had an HRCT scan. Based on history and HRCT findings, subjects were categorised as no previous PTB (NPTB, n=31), probable previous PTB (n=33) or definite previous PTB (DPTB, n=39). Subjects with DPTB had a lower diffusing capacity (Δ=–17.7%; p=0.001) and inspiratory capacity (Δ=–21.5%; p=0.001) than NPTB subjects, and higher gas-trapping and fibrosis but not emphysema scores (Δ=+6.2% (p=0.021), +0.36% (p=0.017) and +3.5% (p=0.098), respectively). Conclusions. The mechanisms of CAL associated with previous PTB appear to differ from those in the more common smoking-related COPD and warrant further study.pt_PT
dc.description.abstract.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.7196/SAMJ.2017.v107i5.12118pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9438
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationA CLINICAL, RADIOLOGICAL AND PATHOPHYSIOLOGICAL STUDY OF CHRONIC OBSTRUCTIVE LUNG DISEASE IN A COHORT OF PATIENTS WITH HIV INFECTION RECEIVING ANTIRETROVIRAL TREATMENT
dc.relation.publisherversionhttp://www.samj.org.za/index.php/samj/article/view/11885pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectCOPDpt_PT
dc.titleObstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA CLINICAL, RADIOLOGICAL AND PATHOPHYSIOLOGICAL STUDY OF CHRONIC OBSTRUCTIVE LUNG DISEASE IN A COHORT OF PATIENTS WITH HIV INFECTION RECEIVING ANTIRETROVIRAL TREATMENT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBSAB%2F976%2F2010/PT
oaire.citation.endPage445pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage440pt_PT
oaire.citation.titleSouth African Medical Journalpt_PT
oaire.citation.volume107pt_PT
person.familyNameTaborda Barata
person.familyNameSaid-Hartley
person.familyNamevan Zyl-Smit
person.familyNamevan Rikxoort
person.familyNameGoldin
person.familyNameBATEMAN
person.givenNameLuis
person.givenNameMariam Qonita
person.givenNameRichard
person.givenNameEva
person.givenNameJonathan
person.givenNameERIC
person.identifier104007
person.identifier.ciencia-id1E1F-8A43-055B
person.identifier.orcid0000-0001-6649-8890
person.identifier.orcid0000-0001-5962-5222
person.identifier.orcid0000-0002-4115-5362
person.identifier.orcid0000-0001-6418-9760
person.identifier.orcid0000-0003-3007-9947
person.identifier.orcid0000-0002-5064-5849
person.identifier.ridP-2640-2014
person.identifier.scopus-author-id15128160500
person.identifier.scopus-author-id57490396000
person.identifier.scopus-author-id6603972670
person.identifier.scopus-author-id7004374200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationc3b9fc67-7761-466f-92c4-c095c2fd3092
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