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Chitosan based-asymmetric membranes for wound healing: a review

2019-01-17Artigo científico Acesso restrito
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dc.contributor.authorMiguel, Sónia
dc.contributor.authorMoreira, André
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-01-17T11:41:44Z
dc.date.available2019-01-17T11:41:44Z
dc.date.issued2019-01-17
dc.description.abstractThe wound healing process involves highly complex and dynamic events that allow the re-establishment of skin's structural integrity. To further improve or to overcome the drawbacks associated with this process, researchers have been focused on the development of new therapeutics. Among them, asymmetric membranes are currently one of the most promising approaches to be used in wound healing due to its structural similarities with the epidermal and dermal layers of the native skin. The outer layer of asymmetric membranes provides a barrier that protects the wound from external damages (e.g. microorganisms and chemical agents), whereas the interior porous layer acts as template for supporting cell adhesion, migration and proliferation. Among the different materials used to produce these distinct layers, the chitosan arises as one of the preeminent materials due to its inherent biocompatibility, antibacterial, hemostatic, and healing properties. Therefore, in this review, it is provided an overview of the different chitosan-based asymmetric membranes developed for wound dressing applications. Further, the chitosan modifications to enhance its bioactivity as well as the asymmetric membranes general properties and production techniques are also described.pt_PT
dc.description.abstractSFRH/BD/109482/2015pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiguel, S.P., Moreira, A.F., Correia, I.J. (2019) "Chitosan based-asymmetric membranes for wound healing: a review", International Journal of Biological Macromolecules, in press.pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2019.01.072pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6798
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationFinanciamento base atribuído ao CICS-UBI [UID/Multi/00709/2013]
dc.relationBolsa de Doutoramento FCT: Development of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing [SFRH/BD/109563/2015]
dc.relationBolsa de Doutoramento FCT: Development of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer [SFRH/BD/109482/2015]
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813018366492?via%3Dihubpt_PT
dc.subjectAsymmetric membranespt_PT
dc.subjectChitosanpt_PT
dc.subjectWound healingpt_PT
dc.titleChitosan based-asymmetric membranes for wound healing: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFinanciamento base atribuído ao CICS-UBI [UID/Multi/00709/2013]
oaire.awardTitleBolsa de Doutoramento FCT: Development of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing [SFRH/BD/109563/2015]
oaire.awardTitleBolsa de Doutoramento FCT: Development of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer [SFRH/BD/109482/2015]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameMoreira
person.familyNameCorreia
person.givenNameSónia Alexandra
person.givenNameAndré Ferreira
person.givenNameIlídio Joaquim Sobreira
person.identifierGX0L2QAAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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