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3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

2019-01-21Journal article Restricted access
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dc.contributor.authorNunes, Ana S.
dc.contributor.authorBarros, Andreia
dc.contributor.authorCosta, Elisabete
dc.contributor.authorMoreira, André
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-03-07T17:18:16Z
dc.date.available2022-03-08T01:30:16Z
dc.date.issued2019-01-21
dc.description.abstractThree-dimensional cell culture models, such as spheroids, can be used in the process of the development of new anticancer agents because they are able to closely mimic the main features of human solid tumors, namely their structural organization, cellular layered assembling, hypoxia, and nutrient gradients. These properties imprint to the spheroids an anticancer therapeutics resistance profile, which is similar to that displayed by human solid tumors. In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided. Furthermore, comparisons between the therapeutics resistance profile exhibited by spheroids, and 2D cell cultures are presented. Finally, examples of the therapeutic approaches that have been developed to surpass the drug resistance mechanisms exhibited by spheroids are described.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/bit.26845pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6896
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.subjectDrug resistancept_PT
dc.subjectDrugspt_PT
dc.subjectIn vitro modelspt_PT
dc.subjectSolid tumorspt_PT
dc.subjectSpheroidspt_PT
dc.title3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.conferencePlaceUSApt_PT
oaire.citation.endPage226pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage206pt_PT
oaire.citation.titleBiotechnology and Bioengineeringpt_PT
oaire.citation.volume116pt_PT
oaire.fundingStreamPOR_CENTRO
oaire.fundingStream5876
person.familyNameSousa Barros
person.familyNameda Rocha Costa
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameAndreia Sofia
person.givenNameElisabete Cristina
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idC213-C723-4528
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0522-1705
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs direitos foram cedidos à editora Wileypt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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