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Biocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug release

2021Journal article Open access
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dc.contributor.authorLopes, Mafalda
dc.contributor.authorRestani, Rita
dc.contributor.authorCarvalho, Marco António Paulo de
dc.contributor.authorCorreia, I.J.
dc.contributor.authorRicardo, Ana Aguiar
dc.contributor.authorBonifácio, Vasco
dc.date.accessioned2021-02-22T10:12:30Z
dc.date.available2023-02-20T01:30:19Z
dc.date.issued2021
dc.description.abstractChitosan, a natural and abundant biopolymer has been long explored as a biocompatible material for the preparation of drug delivery devices. This strategy has been mostly accomplished using chemically crosslinked chitosan leading to more stable scaffolds. However, crosslinking has been shown to reduce both biocompatibility and swelling. In this work chitosan was crosslinked with novel biocompatible crosslinkers, based on oligo-oxazolines and glycidyl methacrylate copolymers, leading to patches with a very high swelling capacity. Dexamethasone therapeutics is strongly enhanced by a controlled release administration. This study shows that oligo-oxazoline-crosslinked chitosan is a suitable biomaterial for loading and controlled release of dexamethasone.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.reactfunctpolym.2021.104846pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11112
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationActivPOL - Development of oxazoline and aziridine-based antimicrobial polymers using supercritical carbon dioxide technology
dc.relationJust in Time Dendrimers
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.subjectOligo-oxazolinespt_PT
dc.subjectChitosanpt_PT
dc.subjectCrosslinkingpt_PT
dc.subjectSupercritical carbon dioxidept_PT
dc.subjectDexamethasonept_PT
dc.titleBiocompatible oligo-oxazoline crosslinkers: Towards advanced chitosans for controlled dug releasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleActivPOL - Development of oxazoline and aziridine-based antimicrobial polymers using supercritical carbon dioxide technology
oaire.awardTitleJust in Time Dendrimers
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI%2F73939%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM%2F099452%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.citation.startPage104846pt_PT
oaire.citation.titleReactive and Functional Polymerspt_PT
oaire.citation.volume161pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.familyNameBonifácio
person.givenNameIlídio
person.givenNameAna
person.givenNameVasco Daniel Bigas
person.identifierUMbJ1KMAAAAJ
person.identifier239073
person.identifierbit.ly/google_scholar_bonifacio
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.ciencia-idAE14-EB30-86A6
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.orcid0000-0003-2349-8473
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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