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IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro

2003-10-01Journal article Open access
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dc.contributor.authorAlves, N L
dc.contributor.authorHooibrink, Berend
dc.contributor.authorArosa, FA
dc.contributor.authorVan Lier, Rene
dc.date.accessioned2025-02-24T10:10:00Z
dc.date.available2025-02-24T10:10:00Z
dc.date.issued2003-10-01
dc.description.abstractRecent studies in mice have shown that although interleukin 15 (IL-15) plays an important role in regulating homeostasis of memory CD8+ T cells, it has no apparent function in controlling homeostatic proliferation of naive T cells. We here assessed the influence of IL-15 on antigen-independent expansion and differentiation of human CD8+ T cells. Both naive and primed human T cells divided in response to IL-15. In this process, naive CD8+ T cells successively down-regulated CD45RA and CD28 but maintained CD27 expression. Concomitant with these phenotypic changes, naive cells acquired the ability to produce interferon γ (IFN-γ) and tumor necrosis factor α (TNF-α), expressed perforin and granzyme B, and acquired cytotoxic properties. Primed CD8+ T cells, from both noncytotoxic (CD45RA-CD27+) and cytotoxic (CD45RA+CD27-) subsets, responded to IL-15 and yielded ample numbers of cytokine-secreting and cytotoxic effector cells. In summary, all human CD8+ T-cell subsets had the ability to respond to IL-15, which suggests a generic influence of this cytokine on CD8+ T-cell homeostasis in man. (Blood. 2003;102:2541-2546).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1182/blood-2003-01-0183pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/15117
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe American Society of Hematologypt_PT
dc.relationPROGRAMA GRADUADO EM ÁREAS DA BIOLOGIA BÁSICA E APLICADA GABBA
dc.subjectGene Expressionpt_PT
dc.subjectImmunobiologypt_PT
dc.subjectImmunotherapypt_PT
dc.titleIL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitropt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePROGRAMA GRADUADO EM ÁREAS DA BIOLOGIA BÁSICA E APLICADA GABBA
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCTI/SFRH%2FBD%2F2740%2F2000/PT
oaire.citation.endPage2546pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage2541pt_PT
oaire.citation.titleBloodpt_PT
oaire.citation.volume102pt_PT
oaire.fundingStreamPOCTI
person.familyNameAlves
person.familyNameHooibrink
person.familyNameArosa
person.familyNamevan Lier
person.givenNameNuno Lages
person.givenNameBerend
person.givenNameFernando
person.givenNameRene
person.identifier83032
person.identifier.ciencia-idDB1E-1B17-0B90
person.identifier.ciencia-id451A-408C-36AB
person.identifier.orcid0000-0002-1567-8389
person.identifier.orcid0000-0002-1922-4966
person.identifier.orcid0000-0002-7209-4507
person.identifier.orcid0000-0002-3201-7144
person.identifier.ridJ-9980-2013
person.identifier.ridE-5640-2010
person.identifier.scopus-author-id7006403392
person.identifier.scopus-author-id6604045863
person.identifier.scopus-author-id7103180610
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0f7d6a61-cd7b-40d3-a452-61b8efaa533c
relation.isAuthorOfPublicationabdbab41-ccdf-492d-a955-b218b7a934ab
relation.isAuthorOfPublication21581c53-bb88-4c42-a41a-911215411178
relation.isAuthorOfPublicationfd57b224-0cf9-4a25-8b79-b88457d244c5
relation.isAuthorOfPublication.latestForDiscoveryabdbab41-ccdf-492d-a955-b218b7a934ab
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