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Genotypic and phenotypic features of Arcobacter butzleri pathogenicity

2014Journal article Restricted access
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dc.contributor.authorFerreira, Susana
dc.contributor.authorQueiroz, João
dc.contributor.authorOleastro, Mónica
dc.contributor.authorDomingues, F.C.
dc.date.accessioned2020-01-29T14:40:44Z
dc.date.available2020-01-29T14:40:44Z
dc.date.issued2014
dc.description.abstractEven though Arcobacter butzleri has been implicated in some human disease as diarrhoea and bacteraemia, much of its pathogenesis and virulence factors remain unclear. In this work we have compared pathogenic and genotypic properties of six A. butzleri isolates from human and non-human sources. The tested isolates showed to be susceptible to tetracyclines and aminoglycosides, however non-human isolates were all resistant to quinolones. The ability to form biofilms was variable among the tested strains, and all of them showed a weak haemolytic activity. The presence of nine putative virulence genes was determined, with cadF, ciaB, cj1349, mviN, pldA, tlyA being detected in all strains, while irgA (3/6), hecA (5/6), hecB (4/6) were detected only in some strains. High levels of adhesion were observed for A. butzleri on Caco-2 cells, with pre-existing inflammation showing no significant effect on the adherence ability; yet variable levels of invasion were observed. A. butzleri isolates were able to survive intracellularly in Caco-2 cells and to induce a significant up-regulation of interleukin-8 secretion and structural cell rearrangements. These data brings new insights on A. butzleri virulence and highlights its pathogenic potential.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.micpath.2014.09.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8896
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0882401014001284pt_PT
dc.subjectArcobacter butzleript_PT
dc.subjectVirulence Factorspt_PT
dc.subjectInflammationpt_PT
dc.subjectIntracellular survivalpt_PT
dc.subjectInvasionpt_PT
dc.subjectAdhesionpt_PT
dc.titleGenotypic and phenotypic features of Arcobacter butzleri pathogenicitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66857%2F2009/PT
oaire.citation.endPage25pt_PT
oaire.citation.startPage19pt_PT
oaire.citation.titleMicrobial Pathogenesispt_PT
oaire.citation.volume76pt_PT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameFerreira
person.familyNameQueiroz
person.familyNameOleastro
person.familyNameDomingues
person.givenNameSusana
person.givenNameJoão
person.givenNameMónica
person.givenNameFernanda
person.identifier269435
person.identifier.ciencia-idF718-3569-E911
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person.identifier.orcid0000-0001-8308-2862
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0001-6360-2576
person.identifier.orcid0000-0002-9540-0853
person.identifier.ridA-6810-2016
person.identifier.ridL-3104-2014
person.identifier.ridN-7295-2013
person.identifier.scopus-author-id34874668400
person.identifier.scopus-author-id7003705645
person.identifier.scopus-author-id6603067224
person.identifier.scopus-author-id10139481400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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