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3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration

2016-06-03Journal article Restricted access
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dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorFigueira, Daniela Sofia Rodrigues
dc.contributor.authorSá, Kevin
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorFradique, Ricardo Gil
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2018-03-21T12:19:26Z
dc.date.available2018-03-21T12:19:26Z
dc.date.issued2016-06-03
dc.description.abstractNowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient’s quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection. To vanquish these drawbacks, researchers from tissue engineering area are currently using computer-aided design models or medical data to produce 3D scaffolds by Rapid Prototyping (RP). Herein, Tricalcium phosphate (TCP)/Sodium Alginate (SA) scaffolds were produced using RP and subsequently functionalized with silver nanoparticles (AgNPs) through two different incorporation methods. The obtained results revealed that the composite scaffolds produced by direct incorporation of AgNPs are the most suitable for being used in bone tissue regeneration since they present appropriate mechanical properties, biocompatibility and bactericidal activity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCorreia, T. R., Figueira, D. R., de Sá, K. D., Miguel, S. P., Fradique, R. G., Mendonça, A. G., e Correia, I. J. (2016) “3D printed scaffolds with bactericidal activity aimed for bone tissue regeneration.” International Journal of Biological Macromolecules, Vol. 93 (Part B), pp. 1432-1445pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2016.06.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4685
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S014181301630530Xpt_PT
dc.subjectBactericidal activitypt_PT
dc.subjectBone regenerationpt_PT
dc.subjectSilver nanoparticlespt_PT
dc.subjectRapid prototyping (RP)pt_PT
dc.title3D Printed scaffolds with bactericidal activity aimed for bone tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1445pt_PT
oaire.citation.startPage1432pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume93pt_PT
person.familyNameCorreia
person.familyNameSá
person.familyNamePereira Miguel
person.familyNameFradique
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.givenNameTiago
person.givenNameKevin
person.givenNameSónia Alexandra
person.givenNameRicardo
person.givenNameAntónio
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-6331-2034
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id55797637100
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id7003557499
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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