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3D scaffolds coated with nanofibers displaying bactericidal activity for bone tissue applications

2016-09-10Journal article Restricted access
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dc.contributor.authorSá, Kevin
dc.contributor.authorFigueira, Daniela Sofia Rodrigues
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, Tiago R.
dc.contributor.authorSilva, Abílio Manuel Pereira da
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2018-03-21T16:39:05Z
dc.date.available2018-03-21T16:39:05Z
dc.date.issued2016-09-10
dc.description.abstractBone-limited capacity to fully repair large defects requires the development of new implants. In this context, new approaches have been used to promote bone regeneration and also to avoid the side effects associated with the therapeutics currently used in the clinic. Herein, 3D tricalcium phosphate/alginic acid scaffolds were produced and then coated with an electrospun mesh loaded with two different antibacterial agents, silver nanoparticles, and salicylic acid. The obtained results showed that the produced scaffolds have suitable mechanical properties, swelling, biodegradation, biomineralization activity, enhanced cellular adhesion/proliferation and bactericidal activity, and features essential for bone regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDe Sá, K. D., Figueira, D. R., Miguel, S. P., Correia, T. R., Silva, A. P., e Correia, I. J. (2017) “3D Scaffolds Coated with Nanofibers Displaying Bactericidal Activity for Bone Tissue Applications.” International Journal of Polymeric Materials and Polymeric Biomaterials, Vol.66 (9), pp.432-442pt_PT
dc.identifier.doi10.1080/00914037.2016.1236338pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4691
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation.publisherversionhttps://www.tandfonline.com/doi/abs/10.1080/00914037.2016.1236338pt_PT
dc.subjectBactericidal activitypt_PT
dc.subjectBone regenerationpt_PT
dc.subjectElectrospinningpt_PT
dc.subjectRapid prototypingpt_PT
dc.subjectSalicylic acidpt_PT
dc.subjectSilver nanoparticlespt_PT
dc.title3D scaffolds coated with nanofibers displaying bactericidal activity for bone tissue applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.endPage442pt_PT
oaire.citation.startPage432pt_PT
oaire.citation.titleInternational Journal of Polymeric Materials and Polymeric Biomaterialspt_PT
oaire.citation.volume66pt_PT
oaire.fundingStreamPOR_CENTRO
person.familyNameSá
person.familyNamePereira Miguel
person.familyNameCorreia
person.familyNameJoaquim Sobreira Correia
person.givenNameKevin
person.givenNameSónia Alexandra
person.givenNameTiago
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id491D-AA5E-FBC0
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-4077-4698
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id55670188900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication3956033a-4abf-439b-a4fd-25c5bd9d8e7a
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