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Towards the development of electrospun mats from poly(ε-caprolactone)/poly(ester amide)s miscible blends

2018-07-18Journal article Restricted access
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dc.contributor.authorLamas, Miguel
dc.contributor.authorLima, Mafalda S.
dc.contributor.authorPinho, AC
dc.contributor.authorTugushi, David
dc.contributor.authorKatsarava, Ramaz
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorSerra, Armenio
dc.contributor.authorCoelho, Jorge
dc.contributor.authorFonseca, Ana C.
dc.date.accessioned2018-08-23T09:01:20Z
dc.date.available2018-08-23T09:01:20Z
dc.date.issued2018-07-18
dc.description.abstractIn this work, electrospun mats made from miscible poly(ε-caprolactone) (PCL)/poly(ester amide) (PEA) blends were prepared, for the first time. The well-known immiscibility issues between these two type of polymers were overcome through the synthesis of a novel tailor-made compatibilizer blocky PEA, comprising well defined PCL and PEA8L6 blocks (PCL-PEA8L6). The PCL-PEA8L6 was synthesized for the first time in this work and was characterized in terms of its chemical structure and thermal properties. Regarding the mats, it was found that their properties (morphology, porosity, wettability, thermomechanical) can be easily adjusted by the ratio of the components of the mixture to be electrospun. Increasing amounts of PEA led to more hydrophilic mats, with enhanced in vitro degradability, both hydrolytic and enzymatic. The in vitro cytotoxicity tests carried out with normal human dermal fibroblasts (NHDF) revealed that the samples do not elicit any acute adverse effect on the cells. Moreover, the NHDF were able to grow and proliferate in the surface of the electrospun mats. The data presented in this contribution is a proof-of-concept that can be used to address immiscibility issues between different types of polymers broadly used in biomedical applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLamas, M.L., Lima, M.S., Pinho, A.C., Tugushi, D., Katsarava, R., Costa, E.C., Correia, I.J., Serra, A.C., Coelho, J. F. J., Fonseca, A.C. (2018) "Towards the development of electrospun mats from poly(ε-caprolactone)/poly(ester amide)s miscible blends", Polymer, Vol. 150, pp. 343-359pt_PT
dc.identifier.doi10.1016/j.polymer.2018.07.050pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/5681
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSynthesis of novel biodegradable polyesters with enhanced mechanical and thermal properties based on renewable monomers: structure/properties relationships
dc.relationPERIPHERAL NERVE REGENERATION - DEVELOPMENT AND EVALUATION OF BIODEGRADABLE POLYMERS GUIDE-TUBE
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relationHealth Sciences Research Centre
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0032386118306529#!pt_PT
dc.subjectPoly(ester amide)spt_PT
dc.subjectPoly(ε-caprolactone)pt_PT
dc.subjectElectrospinningpt_PT
dc.subjectImmiscibility issuespt_PT
dc.subjectBlocky poly(ester amide)spt_PT
dc.titleTowards the development of electrospun mats from poly(ε-caprolactone)/poly(ester amide)s miscible blendspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSynthesis of novel biodegradable polyesters with enhanced mechanical and thermal properties based on renewable monomers: structure/properties relationships
oaire.awardTitlePERIPHERAL NERVE REGENERATION - DEVELOPMENT AND EVALUATION OF BIODEGRADABLE POLYMERS GUIDE-TUBE
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F99982%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/PD%2FBD%2F52626%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage359pt_PT
oaire.citation.startPage343pt_PT
oaire.citation.titlePolymerpt_PT
oaire.citation.volume150pt_PT
oaire.fundingStreamFARH
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oaire.fundingStream6817 - DCRRNI ID
person.familyNameLamas
person.familyNameSilva de Lima
person.familyNameSilva Pinho
person.familyNametugushi
person.familyNameKatsarava
person.familyNameda Rocha Costa
person.familyNameJoaquim Sobreira Correia
person.familyNameSerra
person.familyNameJordão Coelho
person.familyNameAmaral Loureiro da Fonseca
person.givenNameMiguel
person.givenNameMafalda
person.givenNameAna Catarina
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person.givenNameRamaz
person.givenNameElisabete Cristina
person.givenNameIlídio
person.givenNameArmenio
person.givenNameJorge Fernando
person.givenNameAna Clotilde
person.identifierAAF-3923-2021
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project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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