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POxylated graphene oxide nanomaterials for combination chemo-phototherapy of breast cancer cells

2018-08-19Journal article Restricted access
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dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorAlves, Cátia
dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorFerreira, Paula
dc.contributor.authorLouro, Ricardo
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-08-23T10:19:09Z
dc.date.available2018-08-23T10:19:09Z
dc.date.issued2018-08-19
dc.description.abstractPEGylated graphene oxide (GO) nanomaterials have been showing promising results in cancer therapy, due to their drug loading and photothermal capacities. However, the recent reports regarding the immunogenicity of poly(ethylene glycol) based coatings highlight the importance of investigating alternative materials to functionalize GO. Herein, GO derivatives were functionalized for the first time with an amphiphilic polymer based on poly(2-ethyl-2-oxazoline) and were co-loaded with doxorubicin (DOX) and D-α-Tocopherol succinate (TOS) to be applied in chemo-phototherapy of breast cancer cells. The results revealed that POxylated GO displays the required properties for application in cancer therapy. Moreover, the screening of different DOX:TOS combination ratios showed that the 1:3 DOX:TOS molar ratio produces an optimal synergistic therapeutic effect towards breast cancer cells. Furthermore, this drug ratio had a lower impact on normal cells. POxylated GO was then loaded with this drug combination in order to assess its chemo-phototherapeutic potential. The delivery of DOX:TOS by POxylated GO to cancer cells induced a stronger therapeutic effect than that attained with the free drug combination. Furthermore, an even greater cytotoxicity towards cancer cells was achieved by exposing DOX:TOS loaded POxylated GO to near infrared radiation. Overall, POxylated GO is a promising drug delivery and phototherapeutic agent.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDe Melo-Diogo, D., Costa, E.C., Alves, C.G., Lima-Sousa, R., Ferreira, P., Louro, R.O., Correia, I.J. (2018) "POxylated Graphene Oxide Nanomaterials for Combination Chemo-Phototherapy of Breast Cancer Cells", European Journal of Pharmaceutics and Biopharmaceutics, Vol. 131, 162-169.pt_PT
dc.identifier.doi10.1016/j.ejpb.2018.08.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/5687
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0939641118306064pt_PT
dc.subjectCancer treatmentpt_PT
dc.subjectPOxylationpt_PT
dc.subjectGraphene oxidept_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectCo-deliverypt_PT
dc.titlePOxylated graphene oxide nanomaterials for combination chemo-phototherapy of breast cancer cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.endPage169pt_PT
oaire.citation.startPage162pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume131pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMiguel de Melo Diogo
person.familyNameda Rocha Costa
person.familyNameAlves
person.familyNameSousa
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameLouro
person.familyNameJoaquim Sobreira Correia
person.givenNameDuarte
person.givenNameElisabete Cristina
person.givenNameCátia Gomes
person.givenNameAna Rita Lima
person.givenNamePaula
person.givenNameRicardo
person.givenNameIlídio
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person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-2392-6450
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id6603724134
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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