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Photocurable Polymeric Blends for Surgical Application

2020-12-12Journal article Open access
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dc.contributor.authorCernadas, Teresa
dc.contributor.authorSantos, Marta
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorAlves, Patrícia
dc.contributor.authorFerreira, Paula
dc.date.accessioned2021-01-21T17:00:06Z
dc.date.available2021-01-21T17:00:06Z
dc.date.issued2020-12-12
dc.description.abstractThe preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/ma13245681pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11050
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCoimbra Chemistry Center
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPhotocuringpt_PT
dc.subjectPolymeric blendspt_PT
dc.subjectBioadhesivept_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectAntibacterial activitypt_PT
dc.titlePhotocurable Polymeric Blends for Surgical Applicationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCoimbra Chemistry Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/RECI%2FQEQ-QFI%2F0168%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00313%2F2019/PT
oaire.citation.conferencePlaceSwisspt_PT
oaire.citation.issue24pt_PT
oaire.citation.startPage5681pt_PT
oaire.citation.titleMaterialspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStreamCOMPETE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCernadas
person.familyNameSantos
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.familyNameAlves
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNameMaria Teresa
person.givenNameMarta
person.givenNameSónia Alexandra
person.givenNameIlídio
person.givenNamePatrícia
person.givenNamePaula
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
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person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0003-2704-7290
person.identifier.orcid0000-0002-1079-3070
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id57207052926
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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