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Production and characterization of polycaprolactone- hyaluronic acid/chitosan-zein electrospun bilayer nanofibrous membrane for tissue regeneration

2016-09-22Journal article Restricted access
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dc.contributor.authorFigueira, Daniela Sofia Rodrigues
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorSá, Kevin
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-21T15:27:08Z
dc.date.available2018-03-21T15:27:08Z
dc.date.issued2016-09-22
dc.description.abstractA bilayered electrospun membrane was produced in this study, using the electrospinning technique, to be applied as a skin substitute. The upper layer of the membrane was comprised by hyaluronic acid and polycaprolactone in order to provide mechanical support and also to act as a physical barrier against external threats. Chitosan and zein were used to produce the bottom layer that was loaded with salicylic acid, in order to confer anti-inflammatory and antimicrobial activity to this layer. The physicochemical properties of the membranes were determined and the obtained results showed that the produced electrospun membrane display an ideal porosity, appropriate mechanical properties, controlled water loss and a suitable salicylic acid release profile. In addition, membranes did not exhibit any toxic effects for human fibroblast cells, since cells were able to adhere, spread and proliferate. Furthermore, no biofilm formation was noticed on membranes’ surface along the experiments. In conclusion, the gathered data reveal that this electrospun membrane has suitable properties to be used as a wound dressing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFigueira, D. R., Miguel, S. P., de Sá, K. D., e Correia, I. J. (2016) “Production and characterization of polycaprolactone-hyaluronic acid/chitosan-zein electrospun bilayer nanofibrous membrane for tissue regeneration.” International Journal of Biological Macromolecules, Vol.93 (Part A), pp.1100-1110pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2016.09.080pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4688
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813016309382?via%3Dihubpt_PT
dc.subjectBilayer membranept_PT
dc.subjectHuman fibroblast cellspt_PT
dc.subjectWound healingpt_PT
dc.titleProduction and characterization of polycaprolactone- hyaluronic acid/chitosan-zein electrospun bilayer nanofibrous membrane for tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.endPage1110pt_PT
oaire.citation.startPage1100pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume93pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameSá
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameKevin
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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