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Assessment of the Antimicrobial Activity of L. and (L.) DC Extracts and Their Synergistic Potential with Conventional Antibiotics Against

2025-11-24Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorCoimbra, Alexandra
dc.contributor.authorLuís, Ângelo
dc.contributor.authorGaspar, Pedro Dinis
dc.contributor.authorFerreira, Susana
dc.contributor.authorDuarte, Ana Paula
dc.contributor.editorHadjikakou, Sotiris K.
dc.date.accessioned2026-02-06T12:17:09Z
dc.date.available2026-02-06T12:17:09Z
dc.date.issued2025-11-24
dc.description.abstractThis study aimed to evaluate the antibacterial activity of L. and (L.) DC extracts against , including methicillin-resistant (MRSA) strains. To this end, assays were conducted to assess killing kinetics, antibiotic combination effects, modulatory effects on ethidium bromide, inhibition of quorum sensing, and biofilm formation. extract demonstrated the strongest activity, with MIC values ranging from 7.8 to 62.5 µg/mL. When combined with antibiotics such as ampicillin, ciprofloxacin, or vancomycin, the extracts of and predominantly exhibited synergistic (FICI value ≤ 0.5) or additive effects (0.5 < FICI ≤ 1), with some combinations resensitizing resistant strains. The aerial parts of displayed modulatory effects on ethidium bromide MIC, reducing the concentration from 32 to 8 µg/mL, suggesting efflux pump inhibitory activity. In addition, this extract displayed slight quorum-sensing inhibition at a concentration of 125 µg/mL. Moreover, and extracts inhibit the formation of biofilm by strains, even at subinhibitory concentrations (0.5× and 0.25× MIC). The presence of compounds such as myricetin 3 -galactoside, catechin derivatives, gallic acid, kaempferol, and chlorogenic acid in the extracts may contribute to their anti- activity. These results demonstrated the dual antimicrobial and antivirulence potential of and extracts, highlighting their promise as therapeutic agents or adjuvants against These extracts can be promising candidates for further studies on the development of novel strategies targeting multiple pathogenic pathways.
dc.description.sponsorshipProject Montanha Viva-Sistema Previsional Inteligente de Suporte à Decisão em Sustentabilidade”, project PD21-00009, promoted by PROMOVE program funded by Fundação La Caixa and supported by Fundação para a Ciência e a Tecnologia and BPI.
dc.identifier.citationCoimbra, A., Luís, Â., Gaspar, P. D., Ferreira, S., & Duarte, A. P. (2025). Assessment of the Antimicrobial Activity of Cistus salviifolius L. and Helichrysum stoechas (L.) DC Extracts and Their Synergistic Potential with Conventional Antibiotics Against Staphylococcus aureus. International Journal of Molecular Sciences, 26(23), 11331. https://doi.org/10.3390/ijms262311331
dc.identifier.doi10.3390/ijms262311331
dc.identifier.other41373492
dc.identifier.urihttp://hdl.handle.net/10400.6/19863
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre [UIDB/00709/2020]
dc.relationHealth Sciences Research Centre [UIDP/00709/2020]
dc.relationCentre for Mechanical and Aerospace Science and Technologies [UIDB/00151/2020]
dc.relationCentre for Mechanical and Aerospace Science and Technologies [UIDP/00151/2020]
dc.relation.hasversionhttps://www.mdpi.com/1422-0067/26/23/11331
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCistus salviifolius
dc.subjectHelichrysum stoechas
dc.subjectStaphylococcus aureus
dc.subjectadjuvant
dc.subjectantimicrobial agent
dc.subjectbiofilm
dc.subjectquorum sensing
dc.subjectvirulence
dc.titleAssessment of the Antimicrobial Activity of L. and (L.) DC Extracts and Their Synergistic Potential with Conventional Antibiotics Againstpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre [UIDB/00709/2020]
oaire.awardTitleHealth Sciences Research Centre [UIDP/00709/2020]
oaire.awardTitleCentre for Mechanical and Aerospace Science and Technologies [UIDB/00151/2020]
oaire.awardTitleCentre for Mechanical and Aerospace Science and Technologies [UIDP/00151/2020]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00151%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00151%2F2020/PT
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCoimbra
person.familyNameLuís
person.familyNameGaspar
person.familyNameFerreira
person.familyNameDuarte
person.givenNameAlexandra
person.givenNameÂngelo Filipe Santos
person.givenNamePedro Dinis
person.givenNameSusana
person.givenNameAna Paula
person.identifier1255684
person.identifier.ciencia-id5E13-71C0-6CDC
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.ciencia-id6111-9F05-2916
person.identifier.ciencia-idF718-3569-E911
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.orcid0000-0003-0652-4342
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0003-1691-1709
person.identifier.orcid0000-0001-8308-2862
person.identifier.orcid0000-0003-3333-5977
person.identifier.ridN-3016-2013
person.identifier.ridA-6810-2016
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id57217294397
person.identifier.scopus-author-id57419570900
person.identifier.scopus-author-id34874668400
person.identifier.scopus-author-id7102602131
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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