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Vascular endothelial growth factors and placenta growth factor in retinal vasculopathies: Current research and future perspectives

2017-12-07Journal article Open access
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dc.contributor.authorMesquita, Joana
dc.contributor.authorSousa, João Paulo Castro de
dc.contributor.authorPereira, Sara Vaz
dc.contributor.authorNeves, Arminda
dc.contributor.authorPassarinha, L A
dc.contributor.authorTomaz, C. T.
dc.date.accessioned2020-02-07T17:07:16Z
dc.date.available2023-01-01T01:30:18Z
dc.date.issued2017-12-07
dc.description.abstractVision loss due to disease or degeneration of the eye (retina, choroid, retinal veins, or macula) is a leading cause of blindness worldwide. In most cases, vision-threatening ocular diseases are accompanied by abnormal changes in the vasculature of the eye, especially the retina, and these conditions are collectively referred to as retinal vasculopathies. Impaired blood supply or hypoxia stimulates angiogenesis in the vascular and non-vascular sections of the eye, which results in neovascularization, leading to conditions such as diabetic retinopathy or age-related macular degeneration. Studies show that vascular endothelial growth factors: VEGF-A, VEGF-B, and placental growth factor (PlGF) are elevated in these diseases, and hence, these factors could be used as markers for disease prognosis and therapy. In this review, we discuss the function of these growth factors in normal development and disease, with focus on ocular disorders and emphasize the importance of accurately determining their levels in the vitreous and serum of patients for correct diagnosis and therapy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.cytogfr.2017.11.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9152
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAngiogenesispt_PT
dc.subjectNeovascularizationpt_PT
dc.subjectOphthalmic disorderspt_PT
dc.subjectVascular Diseasespt_PT
dc.subjectVascular Endothelial Growth Factorspt_PT
dc.subjectVitreous Bodypt_PT
dc.subjectPlacental growth factor (PIGF)pt_PT
dc.titleVascular endothelial growth factors and placenta growth factor in retinal vasculopathies: Current research and future perspectivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage115pt_PT
oaire.citation.startPage102pt_PT
oaire.citation.titleCytokine and Growth Factor Reviewspt_PT
oaire.citation.volume39pt_PT
person.familyNameMesquita
person.familyNameCastro de Sousa
person.familyNameVaz-Pereira
person.familyNamePaulino Passarinha
person.familyNameTomaz
person.givenNameJoana
person.givenNameJoão Paulo
person.givenNameSara
person.givenNameLuís António
person.givenNameCândida
person.identifierhttps://www.researchgate.net/profile/Luis_Passarinha
person.identifier2198714
person.identifier.ciencia-idD81B-D3DE-23D2
person.identifier.ciencia-id621B-74BF-F9A7
person.identifier.ciencia-idFE13-0C44-13D1
person.identifier.orcid0000-0003-0667-0809
person.identifier.orcid0000-0002-0025-1841
person.identifier.orcid0000-0001-6125-5486
person.identifier.orcid0000-0001-6910-7576
person.identifier.orcid0000-0002-0927-2331
person.identifier.ridP-8249-2017
person.identifier.ridF-9367-2014
person.identifier.scopus-author-id56262249200
person.identifier.scopus-author-id55820663800
person.identifier.scopus-author-id12445439600
person.identifier.scopus-author-id7004546303
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationb53f642a-416d-4873-a962-3c1b34306e6f
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relation.isAuthorOfPublication.latestForDiscovery7441ce5b-4553-4e63-aee6-84224b05356e

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