Publication
Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins
| dc.contributor.author | Almeida, Ana Margarida | |
| dc.contributor.author | Queiroz, João | |
| dc.contributor.author | Sousa, Fani | |
| dc.contributor.author | Sousa, Ângela | |
| dc.date.accessioned | 2020-01-09T17:28:29Z | |
| dc.date.available | 2020-01-09T17:28:29Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Cervical cancer is the fourth most common cancer among women worldwide and its development is mainly associated with human papillomavirus infection, a highly sexually transmissible virus. The expression of E6 and E7 viral oncoproteins deregulates cell repairing mechanisms through impairment of tumor suppressor protein functions, such as p53 or retinoblastoma protein. Although the implementation of new preventive vaccines has decreased the infection rate and cervical cancer progression, there are still many women who are affected by this pathology. Nowadays, the main treatment often requires the use of invasive techniques. From well-established strategies, like DNA vaccines and gene therapy, to innovative gene silencing technologies; different methodologies are currently under scrutiny that target the E6 and E7 oncoproteins and/or their modes of action. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.drudis.2019.07.011 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.6/8187 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation | Health Sciences Research Centre | |
| dc.relation | Biosynthesis and purification of minicircle DNA encoding pri-miR-375 for treatment of Human Papillomavirus infection | |
| dc.relation | Platform for the biosynthesis and purification of HPV-16 E6/E7mutant DNA vaccine for cervical cancer treatment or prevention | |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1359644619303101?via%3Dihub | pt_PT |
| dc.title | Cervical cancer and HPV infection: ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Health Sciences Research Centre | |
| oaire.awardTitle | Biosynthesis and purification of minicircle DNA encoding pri-miR-375 for treatment of Human Papillomavirus infection | |
| oaire.awardTitle | Platform for the biosynthesis and purification of HPV-16 E6/E7mutant DNA vaccine for cervical cancer treatment or prevention | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F102284%2F2014/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F102716%2F2014/PT | |
| oaire.citation.endPage | 2057 | pt_PT |
| oaire.citation.issue | 10 | pt_PT |
| oaire.citation.startPage | 2044 | pt_PT |
| oaire.citation.title | Drug Discovery Today | pt_PT |
| oaire.citation.volume | 24 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| person.familyName | Almeida | |
| person.familyName | Queiroz | |
| person.familyName | Sousa | |
| person.familyName | Sousa | |
| person.givenName | Ana Margarida | |
| person.givenName | João | |
| person.givenName | Fani | |
| person.givenName | Ângela | |
| person.identifier | 817754 | |
| person.identifier.ciencia-id | 931E-B66D-E341 | |
| person.identifier.ciencia-id | 991D-2E13-A840 | |
| person.identifier.ciencia-id | FB1F-08DE-23FE | |
| person.identifier.orcid | 0000-0002-9313-6649 | |
| person.identifier.orcid | 0000-0002-3096-8325 | |
| person.identifier.orcid | 0000-0001-9996-2194 | |
| person.identifier.orcid | 0000-0001-9155-7581 | |
| person.identifier.rid | L-3104-2014 | |
| person.identifier.rid | A-2014-2017 | |
| person.identifier.scopus-author-id | 7003705645 | |
| person.identifier.scopus-author-id | 7005110268 | |
| person.identifier.scopus-author-id | 24330268800 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.embargofct | Copyright cedido à editora no momento da publicação | pt_PT |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |
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