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Production and characterization of electrospun silk fibroin based asymmetric membranes for wound dressing applications

2019-01Journal article Restricted access
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dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorSimões, Déborah
dc.contributor.authorMoreira, André
dc.contributor.authorSequeira, Rosa Maria Saraiva
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-12-11T10:07:26Z
dc.date.available2018-12-11T10:07:26Z
dc.date.issued2019-01
dc.description.abstractNowadays, wound dressings with improved properties are under development and among them, asymmetric membranes have gained an increasing interest due to their two-layered structure that mimic both the epidermis and dermis layers of the skin. Herein, a new asymmetric membrane was produced using the electrospinning technique. The top layer was produced with silk fibroin (SF) and poly(caprolactone) to reproduce the dense nature and waterproof ability of the epidermis. On the other hand, the dermis-like bottom layer was manufactured with SF and hyaluronic acid loaded with an herbal drug (thymol (THY)). All the data gathered showed that the produced electrospun asymmetric membrane exhibited the porosity, wettability, and mechanical properties suitable for the healing process. Further, the in vitro data also demonstrated that the human fibroblast is able to adhere and spread at the membranes' surface, thus confirming their biocompatibility. Moreover, the incorporation of THY into the bottom layer of the membrane, improved its antioxidant and antibacterial properties. Overall, the obtained results demonstrate the appropriateness of the produced membrane for wound healing applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiguel, S.P., Simões, D., Moreira, A.F., Sequeira, R. S., Correia, I.J. (2019) "Production and characterization of electrospun Silk Fibroin based asymmetric membranes for wound dressing applications", International Journal of Biological Macromolecules, Vol.121, pp.524-535pt_PT
dc.identifier.doi10.1016/j.ijbiomac.2018.10.041pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6611
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813018349365?via%3Dihubpt_PT
dc.subjectElectrospun asymmetric membranespt_PT
dc.subjectSilk fibroinpt_PT
dc.subjectThymolpt_PT
dc.titleProduction and characterization of electrospun silk fibroin based asymmetric membranes for wound dressing applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.endPage535pt_PT
oaire.citation.startPage524pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume121pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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