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Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing

2019-04-10Journal article Open access
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dc.contributor.authorAlves, P.
dc.contributor.authorSantos, Marta
dc.contributor.authorMendes, Sabrina
dc.contributor.authorMiguel, Sónia
dc.contributor.authorSá, Kevin
dc.contributor.authorCabral, C.S.D.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorFerreira, Paula
dc.date.accessioned2019-05-22T16:12:08Z
dc.date.available2019-05-22T16:12:08Z
dc.date.issued2019-04-10
dc.description.abstractRecently, the biomedical scientists who are working in the skin regeneration area have proposed asymmetric membranes as ideal wound dressings, since they are able to reproduce both layers of skin and improve the healing process as well as make it less painful. Herein, an electrospinning technique was used to produce new asymmetric membranes. The protective layer was composed of a blending solution between polycaprolactone and polylactic acid, whereas the underlying layer was comprised of methacrylated gelatin and chitosan. The chemical/physical properties, the in vitro hemo- and biocompatibility of the nanofibrous membranes were evaluated. The results obtained reveal that the produced membranes exhibited a wettability able to provide a moist environment at wound site. Moreover, the membranes' hemocompatibility and fibroblast cell adhesion, spreading and proliferation at the surface of the membranes were also noticed in the in vitro assays. Such results highlight the suitability of these asymmetric membranes for wound dressing applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/polym11040653pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7092
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/11/4/653pt_PT
dc.subjectElectrospinningpt_PT
dc.subjectAsymmetric membranept_PT
dc.subjectSkin regenerationpt_PT
dc.subjectBiocompatibilitypt_PT
dc.titlePhotocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.conferencePlaceSuiçapt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage653pt_PT
oaire.citation.titlePolymerspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameAlves
person.familyNameSantos
person.familyNamePereira Miguel
person.familyNameSá
person.familyNameCabral
person.familyNameJoaquim Sobreira Correia
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNamePatrícia
person.givenNameMarta
person.givenNameSónia Alexandra
person.givenNameKevin
person.givenNameCátia Solange Duarte
person.givenNameIlídio
person.givenNamePaula
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-id9615-4D56-1273
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0002-1079-3070
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-7153-3272
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id57207052926
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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