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Lignin-enriched tricalcium phosphate/sodium alginate 3D scaffolds for application in bone tissue regeneration

2023-03-31Journal article Open access
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dc.contributor.authorBarroso, A.S. Silva
dc.contributor.authorCabral, Cátia S. D.
dc.contributor.authorFerreira, Paula
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2023-06-12T08:47:44Z
dc.date.issued2023-03-31
dc.description.abstractThe bone is a connective, vascularized, and mineralized tissue that confers protection to organs, and participates in the support and locomotion of the human body, maintenance of homeostasis, as well as in hematopoiesis. However, throughout the lifetime, bone defects may arise due to traumas (mechanical fractures), diseases, and/or aging, which when too extensive compromise the ability of the bone to self-regenerate. To surpass such clinical situation, different therapeutic approaches have been pursued. Rapid prototyping techniques using composite materials (consisting of ceramics and polymers) have been used to produce customized 3D structures with osteoinductive and osteoconductive properties. In order to reinforce the mechanical and osteogenic properties of these 3D structures, herein, a new 3D scaffold was produced through the layer-by-layer deposition of a tricalcium phosphate (TCP), sodium alginate (SA), and lignin (LG) mixture using the Fab@Home 3D-Plotter. Three different TCP/LG/SA formulations, LG/SA ratio 1:3, 1:2, or 1:1, were produced and subsequently evaluated to determine their suitability for bone regeneration. The physicochemical assays demonstrated that the LG inclusion improved the mechanical resistance of the scaffolds, particularly in the 1:2 ratio, since a 15 % increase in the mechanical strength was observed. Moreover, all TCP/LG/SA formulations showed an enhanced wettability and maintained their capacity to promote the osteoblasts' adhesion and proliferation as well as their bioactivity (formation of hydroxyapatite crystals). Such results support the LG inclusion and application in the development of 3D scaffolds aimed for bone regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2023.124258pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13352
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationBiomimetic 3D scaffolds coated with a thermo-responsive hydrogel containing smart pharmaceuticals nanocarriers aimed for bone tissue regeneration
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subject3D scaffoldspt_PT
dc.subjectBone regenerationpt_PT
dc.subjectComposite materialspt_PT
dc.subjectLigninpt_PT
dc.subjectRapid prototypingpt_PT
dc.titleLignin-enriched tricalcium phosphate/sodium alginate 3D scaffolds for application in bone tissue regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleBiomimetic 3D scaffolds coated with a thermo-responsive hydrogel containing smart pharmaceuticals nanocarriers aimed for bone tissue regeneration
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F151024%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.startPage124258pt_PT
oaire.citation.titleInternational Journal of Biological Macromoleculespt_PT
oaire.citation.volume239pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCabral
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameCátia Solange Duarte
person.givenNamePaula
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCedi os direitos à editora da revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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