Repository logo
 
Publication

Vascular Pathways of Testosterone: Clinical Implications

2019-12-09Journal article Open access
Simple item page
dc.contributor.authorLorigo, Margarida
dc.contributor.authorMariana, Melissa
dc.contributor.authorOliveira, Nelson
dc.contributor.authorLemos, Manuel C.
dc.contributor.authorCairrão, Elisa
dc.date.accessioned2020-03-02T10:38:52Z
dc.date.available2020-03-02T10:38:52Z
dc.date.issued2019-12-09
dc.description.abstractCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T in the vascular system. Firstly, the mechanisms involved in the T vasodilator effect will be presented. Then, it will be discussed the association of T with the main risks for CVD, namely metabolic syndrome, type 2 diabetes mellitus, obesity, atherosclerosis, dyslipidaemia and hypertension. Several studies have shown a correlation between low T levels and an increased prevalence of several CVD. These observations suggest that T has beneficial effects on the cardiovascular system and that testosterone replacement therapy may become a therapeutic reality for some of these disorders.pt_PT
dc.description.sponsorshipUBI-Santander Totta (BID/FCS/2018)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12265-019-09939-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9647
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.subjectAndrogenspt_PT
dc.subjectVasorelaxationpt_PT
dc.subjectRisk factorspt_PT
dc.subjectCardiovascular diseasespt_PT
dc.subjectMetabolic syndromept_PT
dc.subjectDiabetes mellituspt_PT
dc.subjectObesitypt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectDyslipidaemiapt_PT
dc.subjectBlood pressurept_PT
dc.titleVascular Pathways of Testosterone: Clinical Implicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.titleJournal of Cardiovascular Translational Researchpt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLorigo
person.familyNameMariana
person.familyNameLemos
person.familyNameCairrao Rodrigues Oliveira
person.givenNameMargarida
person.givenNameMelissa
person.givenNameManuel
person.givenNameMaria Elisa
person.identifierAAB-1164-2020
person.identifier.ciencia-id9517-3DD1-8A12
person.identifier.ciencia-id0410-064E-0400
person.identifier.ciencia-id4B16-606C-8760
person.identifier.ciencia-id0611-71B8-191E
person.identifier.orcid0000-0002-4752-6398
person.identifier.orcid0000-0003-1875-0144
person.identifier.orcid0000-0001-9326-8900
person.identifier.orcid0000-0002-4823-5701
person.identifier.ridD-9861-2013
person.identifier.scopus-author-id57189263496
person.identifier.scopus-author-id35496279500
person.identifier.scopus-author-idScopus Author ID: 23476537500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication91241f35-66fe-4626-8eb6-ffea4288df3e
relation.isAuthorOfPublication1cc297f2-7420-4983-984f-e8599829e0e9
relation.isAuthorOfPublication2b422136-d551-44cf-acac-7fb1a83f47a4
relation.isAuthorOfPublication2718c108-c03e-44a3-98a7-b05366e0fe61
relation.isAuthorOfPublication.latestForDiscovery91241f35-66fe-4626-8eb6-ffea4288df3e
relation.isProjectOfPublication5f81787a-0492-48ee-912a-13b4261dcee1
relation.isProjectOfPublication.latestForDiscovery5f81787a-0492-48ee-912a-13b4261dcee1

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Lorigo2020_Article_VascularPathwaysOfTestosterone.pdf
Size:
1.29 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito
ICI - CICS | Documentos por Auto-Depósito