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Dextran-Based Injectable Hydrogel Composites for Bone Regeneration

2023-11-23Journal article Open access
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dc.contributor.authorAlves, Patrícia
dc.contributor.authorSimão, Ana Filipa
dc.contributor.authorGraça, Mariana F. P.
dc.contributor.authorMariz, Marcos
dc.contributor.authorCorreia, I.J.
dc.contributor.authorFerreira, Paula
dc.date.accessioned2023-12-18T15:29:12Z
dc.date.available2023-12-18T15:29:12Z
dc.date.issued2023-11-23
dc.description.abstractCurrently, bone infections caused by diseases or injuries are a major health issue. In addition, the conventional therapeutic approaches used to treat bone diseases or injuries present several drawbacks. In the area of tissue engineering, researchers have been developing new alternative therapeutic approaches, such as scaffolds, to promote the regeneration of injured tissues. Despite the advantages of these materials, most of them require an invasive surgical procedure. To overcome these problems, the main focus of this work was to develop scaffolds for bone regeneration, which can be applied using injectable hydrogels that circumvent the use of invasive procedures, while allowing for bone regeneration. Throughout this work, injectable hydrogels were developed based on a natural polymer, dextran, along with the use of two inorganic compounds, calcium β-triphosphate and nanohydroxyapatite, that aimed to reinforce the mechanical properties of the 3D mesh. The materials were chemically characterized considering the requirements for the intended application: the swelling capacity was evaluated, the degradation rate in a simulated physiological environment was assessed, and compression tests were performed. Furthermore, vancomycin was incorporated into the polymeric matrices to obtain scaffolds with antibacterial performance, and their drug release profile was assessed. The cytotoxic profile of the hydrogels was assessed by an MTS assay, using osteoblasts as model cells. The data obtained demonstrated that dextran-based hydrogels were successfully synthesized, with a drug release profile with an initial burst between 50 and 80% of the drug. The hydrogels possess fair biocompatibility. The swelling capacity showed that the stability of the samples and their degradation profile is compatible with the average time period required for bone regeneration (usually about one month) and have a favorable Young’s modulus (200–300 kPa). The obtained hydrogels are well-suited for bone regeneration applications such as infections that occur during implantation or bone graft substitutes with antibiotics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/polym15234501pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13835
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCoimbra Chemistry Center
dc.relationSmart/stimuli-responsive liposome loaded hydrogels with dual delivery potential for tissue engineering applications
dc.relationUC-NMR: a voyage from chemical space to biological function
dc.relationChemical Process Engineering and Forest Products Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOxidized dextranpt_PT
dc.subjectInjectable hydrogelspt_PT
dc.subjectBone regenerationpt_PT
dc.subjectDrug releasept_PT
dc.titleDextran-Based Injectable Hydrogel Composites for Bone Regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCoimbra Chemistry Center
oaire.awardTitleSmart/stimuli-responsive liposome loaded hydrogels with dual delivery potential for tissue engineering applications
oaire.awardTitleUC-NMR: a voyage from chemical space to biological function
oaire.awardTitleChemical Process Engineering and Forest Products Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00313%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/2022.02495.PTDC/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/RECI%2FQEQ-QFI%2F0168%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00102%2F2020/PT
oaire.citation.issue23pt_PT
oaire.citation.startPage4501pt_PT
oaire.citation.titlePolymerspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876-PPCDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
person.familyNameSimão
person.familyNamePais Graça
person.familyNameMariz
person.familyNameJoaquim Sobreira Correia
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNamePatrícia
person.givenNameAna Filipa
person.givenNameMariana Filipa
person.givenNameMarcos
person.givenNameIlídio
person.givenNamePaula
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-id611F-B0F7-2C15
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0002-0472-9857
person.identifier.orcid0000-0001-7891-6041
person.identifier.orcid0000-0002-1380-1275
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id6507570227
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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