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Development of Thiol-Maleimide hydrogels incorporating graphene-based nanomaterials for cancer chemo-photothermal therapy

2023-02-06Journal article Open access
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dc.contributor.authorCosta, Francisco J. P.
dc.contributor.authorNave, Micaela
dc.contributor.authorSousa, Rita Lima
dc.contributor.authorAlves, Cátia
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorDiogo, Duarte de Melo
dc.date.accessioned2023-04-04T11:21:48Z
dc.date.embargo2025-04-04
dc.date.issued2023-02-06
dc.description.abstractNano-sized materials have been widely explored in the biomedicine field, especially due to their ability to encapsulate drugs intended to be delivered to cancer cells. However, systemically administered nanomaterials face several barriers that can hinder their tumor-homing capacity. In this way, researchers are now focusing their efforts in developing technologies that can deliver the nanoparticles directly into the tumor tissue. Particularly, hydrogels assembled using Thiol-Maleimide Michael type additions are emerging for this purpose due to their capacity to incorporate high nanoparticles’ doses in a compact 3D structure as well as good chemical selectivity, biocompatibility, and straightforward preparation. Nevertheless, such hydrogels have been mostly prepared using synthetic polymers, which is not ideal due to their poor biodegradability. In this work, a novel natural polymer-based Thiol-Maleimide hydrogel was produced for application in breast cancer chemo-photothermal therapy. To obtain natural polymers compatible with this crosslinking chemistry, Hyaluronic acid was endowed with Thiol groups and deacetylated Chitosan was grafted with Maleimide groups. Parallelly, Doxoru- bicin loaded Dopamine-reduced graphene oxide (DOX/DOPA-rGO) was prepared for attaining Near Infrared (NIR) light responsive chemo-photothermal nanoagents. By simply mixing Hyaluronic Acid-Thiol, deacetylated Chitosan-Maleimide and DOX/DOPA-rGO, Thiol-Maleimide crosslinked hydrogels incorporating this nano- material could be assembled (DOX/DOPA-rGO@TMgel). When breast cancer cells were incubated with DOPA- rGO@TMgel and exposed to NIR light (photothermal therapy), their viability was reduced to about 59 %. On the other hand, DOX/DOPA-rGO@TMgel (chemotherapy) reduced cancer cells’ viability to 50 %. In stark contrast, the combined action of DOX/DOPA-rGO@TMgel and NIR light decreased breast cancer cells’ viability to just 21 %, highlighting its chemo-photothermal potential.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ijpharm.2023.122713pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/13289
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCancerpt_PT
dc.subjectChemo-photothermal therapypt_PT
dc.subjectGraphene family nanomaterialspt_PT
dc.subjectMacroscale delivery systemspt_PT
dc.subjectThiol-Maleimide hydrogelspt_PT
dc.titleDevelopment of Thiol-Maleimide hydrogels incorporating graphene-based nanomaterials for cancer chemo-photothermal therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTA-BTA%2F0696%2F2020/PT
oaire.citation.startPage122713pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume635pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
person.familyNamePalácio Costa
person.familyNameNave
person.familyNameSousa
person.familyNameAlves
person.familyNameLopes Melo
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameFrancisco José
person.givenNameMicaela
person.givenNameAna Rita Lima
person.givenNameCátia Gomes
person.givenNameBruna Daniela
person.givenNameIlídio
person.givenNameDuarte
person.identifierUMbJ1KMAAAAJ
person.identifierC2z5x04AAAAJ
person.identifier.ciencia-id4012-E7C6-84BA
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-id5717-CB52-B4E5
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.orcid0000-0003-2703-7738
person.identifier.orcid0000-0002-7834-2532
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-0078-1877
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56266511300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCedi o copyright à revistapt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
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