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UV-crosslinked biomaterials: Functionalized polyethylene glycol for tissue adhesive applications

2025-11-21article Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCernadas, Maria Teresa
dc.contributor.authorFerreira, Mariana
dc.contributor.authorMelo, Bruna Daniela Lopes
dc.contributor.authorde Melo-Diogo, Duarte
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorCalvinho, Paula Cristina Nunes Ferreira
dc.contributor.authorAlves, Patrícia
dc.date.accessioned2025-10-15T10:06:21Z
dc.date.available2025-10-15T10:06:21Z
dc.date.issued2025-11-21
dc.description.abstractSurgeons around the world face the challenge of effectively and securely treat acute wounds. The most used techniques used to reestablish proper tissue continuity and promote healing comprise surgical tape strips and wound suturing or stapling. However, these have different limitations associated, like additional tissue trauma and patient discomfort. Tissue adhesives have emerged as a promising alternative to traditional wound dressings and have been widely explored for their potential to minimize these drawbacks while improving overall outcomes. This study focused on the preparation of photocrosslinkable biomaterials, synthesized from polyethylene glycol (PEG) functionalized with 2-isocyanatoethyl acrylate (AOI), for potential use as tissue adhesives. The synthesized polymers were then crosslinked using two different UV irradiation times (30 and 120 s) to assess how the crosslinking period impacts the final properties of the films. The materials’ chemical composition and thermal and mechanical behavior were further characterized. Rheologic profile, gel content, hydrolytic degradation, and contact angles were assessed. In addition, cytocompatibility evaluation was also conducted. Overall, the obtained data suggest that the newly synthesized tissue adhesives form flexible, homogeneous, and transparent matrices, exhibiting promising properties for potential tissue adhesive applications.por
dc.description.sponsorshipFCT (Fundação para a Ciência e Tecnologia, Portugal) for the financial support to CERES (DOI: 10.54499/UIDB/00102/2020 and DOI: 10.54499/UIDP/00102/2020); CERNAS (DOI: 10.54499/UIDP/00681/2020); CICS-UBI (DOI: 10.54499/UIDB/00709/2020 and 10.54499/UIDP/00709/2020); CEMMPRE (DOI: 10.54499/UIDB/00285/2020 and 10.54499/UIDP/00285/2020), AEROG-LAETA (DOI: 10.54499/LA/P/0079/2020 and 10.54499/UIDB/50022/2020) and ARISE (DOI: 10.54499/LA/P/0112/2020). FCT is also acknowledged for the PhD grant 2022.09787.BD (to T. Cernadas) and 2021.06044.BD (DOI: 10.54499/2021.06044.BD; to Bruna L. Melo), for the Junior Researcher contract 2021.00590.CEECIND (DOI: 10.54499/2021.00590.CEECIND/CP1661/CT0001; to Duarte de Melo-Diogo), and for the institutional scientific employment program-contract CEECINST/00077/2021 (to P. Ferreira) and CEECINSTLA/00023/2022 (to P. Alves). The FCT funded Wastesilk (PTDC/BTABTA/ 0696/2020), GRAPHY (2022.06320.PTDC; DOI: 10.54499/ 2022.06320.PTDC) and SmartLipoGel (2022.02495.PTDC; DOI: 10.54499/2022.02495.PTDC) projects are also acknowledged. For the purpose of Open Access, the authors have applied a CC-BY public copyright license to any Author’s Accepted Manuscript (AAM) version arising from this submission. 1H NMR data were obtained at the Nuclear Magnetic Resonance Laboratory of the Coimbra Chemistry Centre (www.nmrccc.uc.pt), Universidade de Coimbra, supported in part by grant REEQ/481/QUI/2006 from FCT, POCI-2010, and FEDER, Portugal.
dc.identifier.citationCernadas, T., Ferreira, M., Melo, B. L., de Melo-Diogo, D., Correia, I. J., Ferreira, P., & Alves, P. (2025). UV-crosslinked biomaterials: Functionalized polyethylene glycol for tissue adhesive applications. Polymer, 339, 129189.
dc.identifier.doi10.1016/j.polymer.2025.129189
dc.identifier.issn0032-3861
dc.identifier.urihttp://hdl.handle.net/10400.6/18961
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationChemical Process Engineering and Forest Products Research Centre
dc.relationResearch Center in Natural Resources, Environment and Society
dc.relationPolymer-based Photocatalystd for Wastewater Treatment through Light-driven Processes
dc.relationHealth Sciences Research Centre [UIDP/00709/2020]
dc.relationAssociate Laboratory of Energy, Transports and Aeronautics UIDP/50022/2020
dc.relationBolsa de Doutoramento - Biotecnologia Médica
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationCentro de Estudos de Recursos Naturais, Ambiente e Sociedade (CERNAS/ESAC/IPC)
dc.relationSilk Sericin as an industrial wastewater with valuable biomedical potential
dc.relationThiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer
dc.relationSmart/stimuli-responsive liposome loaded hydrogels with dual delivery potential for tissue engineering applications
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0032386125011759#kwrds0010
dc.relation.ispartofPolymer
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePolymer
dc.subjectTissue adhesive
dc.subjectPolyethylene glycol
dc.subjectFunctionalization
dc.subjectPhotocrosslinking
dc.subjectCytocompatibility
dc.titleUV-crosslinked biomaterials: Functionalized polyethylene glycol for tissue adhesive applicationseng
dc.typearticle
dspace.entity.typePublication
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oaire.awardTitlePolymer-based Photocatalystd for Wastewater Treatment through Light-driven Processes
oaire.awardTitleHealth Sciences Research Centre [UIDP/00709/2020]
oaire.awardTitleAssociate Laboratory of Energy, Transports and Aeronautics UIDP/50022/2020
oaire.awardTitleBolsa de Doutoramento - Biotecnologia Médica
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleCentro de Estudos de Recursos Naturais, Ambiente e Sociedade (CERNAS/ESAC/IPC)
oaire.awardTitleSilk Sericin as an industrial wastewater with valuable biomedical potential
oaire.awardTitleThiol-ene click injectable in situ forming hydrogels incorporating graphene: optimization of the polymer-related features for the immuno-photothermal therapy of metastatic breast cancer
oaire.awardTitleSmart/stimuli-responsive liposome loaded hydrogels with dual delivery potential for tissue engineering applications
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oaire.citation.startPage129189
oaire.citation.titlePolymer Journal
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