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Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review

2016-08-31Journal article Restricted access
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dc.contributor.authorMoreira, André
dc.contributor.authorDias, Diana Rodrigues
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-21T14:19:45Z
dc.date.available2018-03-21T14:19:45Z
dc.date.issued2016-08-31
dc.description.abstractThe application of nanocarriers as selective drug delivery platforms, as imaging or as diagnostic agents has been evaluated in several studies in the area of biomedicine, namely for cancer therapy. Such systems have the potential to perform a controlled and site-specific delivery of therapeutic agents leading to a reduction of side effects and, ultimately, to an improved therapeutic outcome. Among the different nanocarriers developed so far, mesoporous silica nanoparticles have attracted the attention of the scientific community for being applied as drug delivery systems that are capable of controlling, both in space and time, the drug release. In this review, the modifications performed, so far, on mesoporous silica nanoparticles to imprint them a stimulus responsive behavior (namely, pH, redox potential, adenosine triphosphate, enzyme or temperature) in order to allow their application in cancer therapy are highlighted.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira, A. F., Dias, D. R., e Correia, I. J. (2016) “Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review.” Microporous and Mesoporous Materials, Vol.236, pp.141-157pt_PT
dc.identifier.doi10.1016/j.micromeso.2016.08.038pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4687
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1387181116303730
dc.subjectCancer therapypt_PT
dc.subjectDrug deliverypt_PT
dc.subjectMesoporous silica nanoparticlespt_PT
dc.subjectStimuli-responsive behaviorpt_PT
dc.titleStimuli-responsive mesoporous silica nanoparticles for cancer therapy: A reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.endPage157pt_PT
oaire.citation.startPage141pt_PT
oaire.citation.titleMicroporous and Mesoporous Materialspt_PT
oaire.citation.volume236pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.givenNameAndré Ferreira
person.givenNameIlídio
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscoverye20bf724-86f1-4fc8-800d-39ff19b624b1
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