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Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Review

2022-05-08Journal article Open access
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dc.contributor.authorAlves, Cátia
dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorMelo, Bruna L.
dc.contributor.authorMoreira, André F.
dc.contributor.authorCorreia, I.J.
dc.contributor.authorDiogo, Duarte de Melo
dc.date.accessioned2023-01-03T14:03:18Z
dc.date.available2023-01-03T14:03:18Z
dc.date.issued2022-05-08
dc.description.abstractThe development of strategies capable of eliminating metastasized cancer cells and preventing tumor recurrence is an exciting and extremely important area of research. In this regard, therapeutic approaches that explore the synergies between nanomaterial-mediated phototherapies and immunostimulants/immune checkpoint inhibitors have been yielding remarkable results in pre-clinical cancer models. These nanomaterials can accumulate in tumors and trigger, after irradiation of the primary tumor with near infrared light, a localized temperature increase and/or reactive oxygen species. These effects caused damage in cancer cells at the primary site and can also (i) relieve tumor hypoxia, (ii) release tumor-associated antigens and danger-associated molecular patterns, and (iii) induced a pro-inflammatory response. Such events will then synergize with the activity of immunostimulants and immune checkpoint inhibitors, paving the way for strong T cell responses against metastasized cancer cells and the creation of immune memory. Among the different nanomaterials aimed for cancer immuno-phototherapy, those incorporating near infrared-absorbing heptamethine cyanines (Indocyanine Green, IR775, IR780, IR797, IR820) have been showing promising results due to their multifunctionality, safety, and straightforward formulation. In this review, combined approaches based on phototherapies mediated by heptamethine cyanine-loaded nanomaterials and immunostimulants/immune checkpoint inhibitor actions are analyzed, focusing on their ability to modulate the action of the different immune system cells, eliminate metastasized cancer cells, and prevent tumor recurrence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves, A. S. C., Rodrigues, C. F., Fernandes, N., de Melo‐Diogo, D., Ferreira, P., Moreira, A. F., & Correia, I. J. (2022). IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/ photodynamic therapy. Biotechnology and Bioengineering, 119, 644–656. https://doi.org/10.1002/bit.27996pt_PT
dc.identifier.doi10.3390/pharmaceutics14051015pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/12574
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationHealth Sciences Research Centre
dc.relationShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/14/5/1015pt_PT
dc.subjectCancerpt_PT
dc.subjectHeptamethine cyaninespt_PT
dc.subjectImmunotherapypt_PT
dc.subjectNanoparticlespt_PT
dc.subjectPhototherapiespt_PT
dc.titleHeptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photodynamic Therapy: A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.06044.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1015pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND4ed
oaire.fundingStreamPOR_CENTRO
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person.familyNameAlves
person.familyNameSousa
person.familyNameLopes Melo
person.familyNameMoreira
person.familyNameJoaquim Sobreira Correia
person.familyNameMiguel de Melo Diogo
person.givenNameCátia Gomes
person.givenNameAna Rita Lima
person.givenNameBruna Daniela
person.givenNameAndré Ferreira
person.givenNameIlídio
person.givenNameDuarte
person.identifier1161643
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person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0002-0078-1877
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9984-3603
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id56266511300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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