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Polyester-based photocrosslinkable bioadhesives for wound closure and tissue regeneration support

2021Journal article Open access
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dc.contributor.authorSantos, M.
dc.contributor.authorCernadas, T.
dc.contributor.authorMartins, P.
dc.contributor.authorP. Miguel, Sónia
dc.contributor.authorCorreia, I.J.
dc.contributor.authorAlves, P.
dc.contributor.authorFerreira, P.
dc.date.accessioned2021-01-21T17:09:25Z
dc.date.available2023-01-21T01:30:19Z
dc.date.issued2021
dc.description.abstractPhotocrosslinkable surgical adhesives provide many advantages when compared with traditional methods used in wound closure. This work aimed to develop UV-curable biodegradable adhesives based on lactic acid and PCL oligomers. Both materials were functionalized with 2-isocyanatoethyl acrylate (AOI). Subsequently, the photoinitiator (Irgacure® 2959) was added to the blend and then, the final materials were irradiated under UV light for two different times: 30 s and 2 min. After production of adhesives, its physicochemical properties were evaluated through FTIR-ATR and TGA, as well as its rheology, dynamic water contact angle, swelling capacity and hydrolytic degradation. Furthermore, the biocompatibility of the produced adhesives was also characterized in contact with human dermal fibroblasts cells. The antimicrobial activity of the materials was assessed by using Staphylococcus aureus and Escherichia coli, as bacterial models.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.reactfunctpolym.2020.104798pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/11051
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationZwitterionic-based amphiphile coated Graphene Oxide nanostructures for chemo-photothermal therapy of breast cancer.
dc.relationResearch Center for Chemical Processes and Forest Products
dc.subjectOligomerspt_PT
dc.subjectFunctionalizationpt_PT
dc.subjectPhotocrosslinkingpt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectAntimicrobial propertiespt_PT
dc.titlePolyester-based photocrosslinkable bioadhesives for wound closure and tissue regeneration supportpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleZwitterionic-based amphiphile coated Graphene Oxide nanostructures for chemo-photothermal therapy of breast cancer.
oaire.awardTitleResearch Center for Chemical Processes and Forest Products
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FNAN-MAT%2F28989%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FEMD-EMD%2F31462%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01432%2F2015%2FCP1314%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FEQU%2F00102%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage104798pt_PT
oaire.citation.titleReactive and Functional Polymerspt_PT
oaire.citation.volume158pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamInvestigador FCT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCernadas
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.familyNameAlves
person.familyNameCristina Nunes Ferreira Calvinho
person.givenNameMaria Teresa
person.givenNameSónia Alexandra
person.givenNameIlídio
person.givenNamePatrícia
person.givenNamePaula
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id8C1C-0ED0-BDA6
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person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.orcid0000-0003-2704-7290
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0003-3393-4427
person.identifier.ridI-1004-2013
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55321888200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à revistapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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