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Physiological markers and multimorbidity

2018-10-23Journal article Open access
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dc.contributor.authorFerreira, Gustavo Dias
dc.contributor.authorSimões, José Augusto Rodrigues
dc.contributor.authorSenaratna, Chamara
dc.contributor.authorPati, Sanghamitra
dc.contributor.authorTimm, Pierre Fernando
dc.contributor.authorBatista, Sandro Rodrigues
dc.contributor.authorNunes, Bruno Pereira
dc.date.accessioned2018-10-30T09:42:31Z
dc.date.available2018-10-30T09:42:31Z
dc.date.issued2018-10-23
dc.date.updated2018-10-28T21:42:28Z
dc.description.abstractBackground: Multimorbidity is the co-occurrence of two or more diseases in the same individual. One method to identify this condition at an early stage is the use of specific markers for various combinations of morbidities. Nonetheless, evidence related to physiological markers in multimorbidity is limited. Objective: The aim was to perform a systematic review to identify physiological markers associated with multimorbidity. Design: Articles available on PubMed, Register of Controlled Trials, Academic Search Premier, CINAHL, Scopus, SocINDEX, Web of Science, LILACS, and SciELO, from their inception to May 2018, were systematically searched and reviewed. The project was registered in PROSPERO under the number CRD42017055522. Results: The systematic search identified 922 papers. After evaluation, 18 articles were included in the full review reporting at least one physiological marker in coexisting diseases or which are strongly associated with the presence of multimorbidity in the future. Only five of these studies examined multimorbidity in general, identifying five physiological markers associated with multimorbidity, namely, dehydroepiandrosterone sulfate (DHEAS), interleukin 6 (IL-6), C-reactive protein (CRP), lipoprotein (Lp), and cystatin C (Cyst-C). Conclusions: There is a paucity of studies related to physiological markers in multimorbidity. DHEAS, IL-6, CRP, Lp, and Cyst-C could be the initial focus for further investigation of physiological markers related to multimorbidity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier2235-042Xen_US
dc.identifier.citationFerreira, Gustavo Dias; Simões, José Augusto; Senaratna, Chamara; Pati, Sanghamitra; Timm, Pierre Fernando; Batista, Sandro Rodrigues; Nunes, Bruno Pereira. Physiological markers and multimorbidity. A systematic review, Journal of Comorbidity, 8, 1, 2235042X1880698-22, 2018.pt_PT
dc.identifier.doi10.1177/2235042X18806986pt_PT
dc.identifier.issn2235-042X
dc.identifier.urihttp://hdl.handle.net/10400.6/6267
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMultimorbiditypt_PT
dc.subjectPhysiological markerspt_PT
dc.subjectComorbiditypt_PT
dc.subjectMolecular markerspt_PT
dc.titlePhysiological markers and multimorbiditypt_PT
dc.title.alternativeA systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEstados Unidospt_PT
oaire.citation.titleJournal of Comorbiditypt_PT
person.familyNameRodrigues Simões
person.givenNameJosé Augusto
person.identifierL-4695-2016
person.identifier.ciencia-idE419-CED2-38BA
person.identifier.orcid0000-0003-2264-7086
person.identifier.scopus-author-id36896116500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication919b504d-aaa9-40ee-a1a5-40e1e0a57f6f
relation.isAuthorOfPublication.latestForDiscovery919b504d-aaa9-40ee-a1a5-40e1e0a57f6f

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