Repository logo
 
Publication

IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy

2017-01-11Journal article Restricted access
Simple item page
dc.contributor.authorSilva, Cleide Isabel Pais
dc.contributor.authorDiogo, Duarte Miguel de Melo
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.date.accessioned2018-03-22T09:02:00Z
dc.date.available2018-03-22T09:02:00Z
dc.date.issued2017-01-11
dc.description.abstractIR780 iodide is a near-infrared (NIR) dye with a huge potential for cancer imaging and phototherapy. However, its biomedical application is strongly impaired by its lipophilic character. Herein, amphiphilic micelles based on d-α-tocopheryl polyethylene glycol succinate (TPGS) and d-α-tocopheryl succinate (TOS), two vitamin E derivatives with intrinsic anticancer activity, are explored to load IR780. IR780-loaded micelles with suitable sizes are obtained by using specific TPGS and TOS weight feed ratios during micelles formulation and these are able to encapsulate IR780 with high efficiency. In in vitro assays, the IR780-loaded micelles induce a cytotoxic effect in cancer cells upon exposure to NIR irradiation through the generation of reactive oxygen species (photodynamic therapy). This effective ablation of cancer cells is achieved using an ultra-low IR780 concentration. Moreover, IR780-loaded micelles also have the ability to act as photothermal and imaging agents, which widens their therapeutic and diagnostic potential. Overall, TPGS-TOS micelles are promising nanoplatforms for IR780-mediated cancer phototherapy and imaging.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPais-Silva, C., de Melo-Diogo e Correia, I. J (2017) “IR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapy.” European Journal of Pharmaceutics and Biopharmaceutics, Vol.113, pp.108-117pt_PT
dc.identifier.doi10.1016/j.ejpb.2017.01.002pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4695
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0939641116304532pt_PT
dc.subjectBreast cancerpt_PT
dc.subjectPhotodynamic therapypt_PT
dc.subjectPhotothermal therapypt_PT
dc.subjectTPGS-TOS micellespt_PT
dc.subjectIR780 iodidept_PT
dc.titleIR780-loaded TPGS-TOS micelles for breast cancer photodynamic therapypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleMULTIFUNCTIONAL GRAPHENE-OXIDE NANOCARRIERS FOR DRUG DELIVERY AND PHOTOTHERMAL THERAPY OF LUNG CANCER
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103506%2F2014/PT
oaire.citation.endPage117pt_PT
oaire.citation.startPage108pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume113pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNamede Melo-Diogo
person.familyNameCorreia
person.givenNameDuarte
person.givenNameIlídio Joaquim Sobreira
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8525f1be-ff8f-4e46-b158-e59928e8a3e5
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscovery8525f1be-ff8f-4e46-b158-e59928e8a3e5
relation.isProjectOfPublication1bea56d9-b91c-42af-a6d6-8004792eaac0
relation.isProjectOfPublicationa61e1cb2-bd08-4ddf-806d-76b237068ee3
relation.isProjectOfPublication.latestForDiscovery1bea56d9-b91c-42af-a6d6-8004792eaac0

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2017 Pais-silva EJPB.pdf
Size:
2.29 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito