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Bioactive Potential of Wild Plants from Gardunha Mountain: Phytochemical Characterization and Biological Activities

2025-09-25Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
dc.contributor.authorCoimbra, Alexandra
dc.contributor.authorGallardo, Eugenia
dc.contributor.authorLuís, Ângelo
dc.contributor.authorGaspar, Pedro Dinis
dc.contributor.authorFerreira, Susana
dc.contributor.authorDuarte, Ana Paula
dc.contributor.editorAdriana, Irinel
dc.date.accessioned2026-02-06T14:38:51Z
dc.date.available2026-02-06T14:38:51Z
dc.date.issued2025-09-25
dc.description.abstractThe plants used in folk medicine have been increasingly studied to identify their bioactive properties. Therefore, this study aimed to assess the bioactivity of the hydroethanolic extracts of plants collected in Gardunha Mountain, Portugal. Seven abundant and representative wild plants were studied: , , , , , , and . The phytochemical composition of the extracts was determined by UHPLC-timsTOF-MS and by spectrophotometric methods. The antioxidant, in vitro anti-inflammatory and antimicrobial activity and the biocompatibility of the extracts were tested. The extracts were predominantly composed of flavonoids and phenolic acids, such as gallic acid, neochlorogenic acid and quercetin glycosides. The extracts demonstrated very strong antioxidant activity related to scavenging free radicals (AAI = 2.84 and 2.93). Regarding antimicrobial activity, the extract exhibited inhibitory effects, particularly against Gram-positive bacteria and yeasts (MIC = 0.008-0.5 mg/mL). The , , and extracts showed low cytotoxicity (viability > 70%) in the highest concentration tested. These findings highlight and as promising sources of novel bioactive compounds, particularly antimicrobials in controlling microbial growth and promoting associated health benefits, and underscore the value of traditional medicinal plants as a guide for pharmacological studies.
dc.description.sponsorship“Montanha Viva-Sistema Previsional Inteligente de Suporte à Decisão em Sustentabilidade”, project PD21-00009, promoted by PROMOVE program funded by Fundação La Caixa and supported by Fundação para a Ciência e a Tecnologia and BPI.
dc.identifier.citationCoimbra, A., Gallardo, E., Luís, Â., Gaspar, P. D., Ferreira, S., & Duarte, A. P. (2025). Bioactive Potential of Wild Plants from Gardunha Mountain: Phytochemical Characterization and Biological Activities. Molecules, 30(19), 3876. https://doi.org/10.3390/molecules30193876
dc.identifier.doi10.3390/molecules30193876
dc.identifier.issn1420-3049
dc.identifier.other41097297
dc.identifier.urihttp://hdl.handle.net/10400.6/19864
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre [UIDB/00709/2020]
dc.relationCICS-UBI [UIDP/00709/2020]
dc.relationHealth Sciences Research Centre [UIDP/00709/2020]
dc.relationCentre for Mechanical and Aerospace Science and Technologies [UIDB/00151/2020]
dc.relation.hasversionhttps://www.mdpi.com/1420-3049/30/19/3876
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectanti-inflammatory activity
dc.subjectantimicrobial activity
dc.subjectantioxidant activity
dc.subjectcytotoxicity
dc.subjectphytochemistry
dc.subjectplant extracts
dc.titleBioactive Potential of Wild Plants from Gardunha Mountain: Phytochemical Characterization and Biological Activitiespor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre [UIDB/00709/2020]
oaire.awardTitleCICS-UBI [UIDP/00709/2020]
oaire.awardTitleHealth Sciences Research Centre [UIDP/00709/2020]
oaire.awardTitleCentre for Mechanical and Aerospace Science and Technologies [UIDB/00151/2020]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00151%2F2020/PT
oaire.citation.titleMolecules
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCoimbra
person.familyNameGallardo
person.familyNameLuís
person.familyNameGaspar
person.familyNameFerreira
person.familyNameDuarte
person.givenNameAlexandra
person.givenNameEugenia
person.givenNameÂngelo Filipe Santos
person.givenNamePedro Dinis
person.givenNameSusana
person.givenNameAna Paula
person.identifier908303
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person.identifier.ciencia-idF718-3569-E911
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.orcid0000-0003-0652-4342
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person.identifier.orcid0000-0003-1691-1709
person.identifier.orcid0000-0001-8308-2862
person.identifier.orcid0000-0003-3333-5977
person.identifier.ridM-7410-2017
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person.identifier.ridB-5904-2009
person.identifier.scopus-author-id57217294397
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person.identifier.scopus-author-id34874668400
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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