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Prototypic Heptamethine Cyanine Incorporating Nanomaterials for Cancer Phototheragnostic

2020-01-29Journal article Open access
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dc.contributor.authorLeitão, Miguel
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorAlves, Cátia
dc.contributor.authorSousa, Ana Rita Lima
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-02-03T16:48:39Z
dc.date.available2022-01-29T01:30:10Z
dc.date.issued2020-01-29
dc.description.abstractDeveloping technologies that allow the simultaneous diagnosis and treatment of cancer (theragnostic) has been the quest of numerous interdisciplinary research teams. In this context, nanomaterials incorporating prototypic near infrared (NIR)-light responsive heptamethine cyanines have been showing very promising results for cancer theragnostic. The precisely engineered features of these nanomaterials endow them with the ability to achieve a high tumor accumulation, enabling a tumor's visualization by NIR fluorescence and photoacoustic imaging modalities. Upon interaction with NIR light, the tumor-homed heptamethine cyanine-incorporating nanomaterials can also produce a photothermal/photodynamic effect with a high spatio-temporal resolution and minimal side effects, leading to an improved therapeutic outcome. This progress report analyses the application of nanomaterials incorporating prototypic NIR-light responsive heptamethine cyanines (IR775, IR780, IR783, IR797, IR806, IR808, IR820, IR825, IRDye 800CW, and Cypate) for cancer photothermal therapy, photodynamic therapy, and imaging. Overall, the continuous development of nanomaterials incorporating the prototypic NIR absorbing heptamethine cyanines will cement their phototheragnostic capabilities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/adhm.201901665pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8970
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.subjectCancerpt_PT
dc.subjectHeptamethine cyaninespt_PT
dc.subjectNIR imagingpt_PT
dc.subjectPhotoacoustic imagingpt_PT
dc.subjectPhototherapiespt_PT
dc.titlePrototypic Heptamethine Cyanine Incorporating Nanomaterials for Cancer Phototheragnosticpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage1901665pt_PT
oaire.citation.titleAdvanced Healthcare Materialspt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameMarques Leitão
person.familyNameMiguel de Melo Diogo
person.familyNameAlves
person.familyNameSousa
person.familyNameJoaquim Sobreira Correia
person.givenNameMiguel
person.givenNameDuarte
person.givenNameCátia Gomes
person.givenNameAna Rita Lima
person.givenNameIlídio
person.identifierC2z5x04AAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A12-D674-B621
person.identifier.ciencia-id9C10-9BD8-634E
person.identifier.ciencia-id8317-7EF2-24C8
person.identifier.ciencia-idBD19-68AA-7099
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0003-1029-4893
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201213407
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright do artigo foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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