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Current progress on microRNAs-based therapeutics in neurodegenerative diseases

2017Journal article Restricted access
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dc.contributor.authorPereira, Patrícia
dc.contributor.authorQueiroz, João
dc.contributor.authorFigueiras, Ana
dc.contributor.authorSousa, Fani
dc.date.accessioned2020-01-09T16:19:25Z
dc.date.available2020-01-09T16:19:25Z
dc.date.issued2017
dc.description.abstractMicroRNAs (miRNAs)-based therapy has recently emerged as a promising strategy in the treatments of neurodegenerative diseases. Thus, in this review, the most recent and important challenges and advances on the development of miRNA therapeutics for brain targeting are discussed. In particular, this review highlights current knowledge and progress in the field of manufacturing, recovery, isolation, purification, and analysis of these therapeutic oligonucleotides. Finally, the available miRNA delivery systems are reviewed and an analysis is presented in what concerns to the current challenges that have to be addressed to ensure their specificity and efficacy. Overall, it is intended to provide a perspective on the future of miRNA-based therapeutics, focusing the biotechnological approach to obtain miRNAs. WIREs RNA 2017, 8:e1409. doi: 10.1002/wrna.1409 For further resources related to this article, please visit the WIREs website.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1002/wrna.1409pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/8176
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/wrna.1409pt_PT
dc.subjectAnimalspt_PT
dc.subjectHumanspt_PT
dc.subjectMicroRNAspt_PT
dc.subjectNeurodegenerative Diseasespt_PT
dc.subjectGenetic Therapypt_PT
dc.titleCurrent progress on microRNAs-based therapeutics in neurodegenerative diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/EXPL%2FQEQ-MED%2F1068%2F2013/PT
oaire.citation.issue3pt_PT
oaire.citation.startPagee1409pt_PT
oaire.citation.titleWiley Interdisciplinary Reviews: RNApt_PT
oaire.citation.volume8pt_PT
oaire.fundingStreamCOMPETE
person.familyNamePereira
person.familyNameQueiroz
person.familyNameFigueiras
person.familyNameSousa
person.givenNamePatrícia
person.givenNameJoão
person.givenNameAna
person.givenNameFani
person.identifier57602
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person.identifier.orcid0000-0002-5665-5271
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0001-8170-1113
person.identifier.orcid0000-0001-9996-2194
person.identifier.ridL-3104-2014
person.identifier.ridK-7332-2014
person.identifier.ridA-2014-2017
person.identifier.scopus-author-id56111844900
person.identifier.scopus-author-id7003705645
person.identifier.scopus-author-id36771870800
person.identifier.scopus-author-id7005110268
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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