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Functionalization of AuMSS nanorods towards more effective cancer therapies

2019-01-15Journal article Restricted access
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dc.contributor.authorRodrigues, Ana Carolina Félix
dc.contributor.authorJacinto, Telma A.
dc.contributor.authorMoreira, André
dc.contributor.authorCosta, Elisabete C.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-01-17T11:51:40Z
dc.date.available2019-01-17T11:51:40Z
dc.date.issued2019-01-15
dc.description.abstractThe application of nanoparticles as selective drug delivery platforms arises as one the most promising therapeutic strategies in the biomedical field. Such systems can encapsulate drugs, prevent its premature degradation, transport and promote the drugs specific delivery to the target site. Among the different nanostructures, gold-core mesoporous silica shell (AuMSS) nanorods have been one of the most explored due to their unique physical and chemical properties. The mesoporous silica biocompatibility, high surface area that can be easily functionalized, tubular pores that can store the drugs, conjugated with the intrinsic capacity of gold nanorod to absorb near-infrared radiation, allows the combination of hyperthermia (i.e., photothermal effect) with drug delivery, making them a nanoplatforms with a huge potential for cancer therapy. Nevertheless, the successful application of AuMSS nanoparticles as an effective cancer nanomedicine is hindered by the uncontrolled release of the therapeutic payloads, limited blood circulation time and unfavorable pharmacokinetics. In this review, an overview of the modifications performed to improve the AuMSS nanorods application in nanomedicine is provided, highlighting the practical approaches that enhanced the AuMSS nanorods targeting, responsiveness to different stimuli, and blood circulation time. Further, the basics of AuMSS nanorods synthesis procedures, general properties, and its application in cancer therapy are also described.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues, C.F., Jacinto, T.A., Moreira, A.F., Costa, E.C., Miguel, S.P., Correia, I.J. (2019) "Functionalization of AuMSS nanorods towards more effective cancer therapies", Nano Research, in presspt_PT
dc.identifier.doi10.1007/s12274-019-2286-ypt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6800
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s12274-019-2286-ypt_PT
dc.subjectGold nanorodspt_PT
dc.subjectCancerpt_PT
dc.subjectSurface modificationspt_PT
dc.subjectTargetingpt_PT
dc.subjectSilicapt_PT
dc.titleFunctionalization of AuMSS nanorods towards more effective cancer therapiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitle3D multicellular spheroids as high throughput platforms to screen novel combinatory therapies for treatment of pancreatic cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F103507%2F2014/PT
oaire.citation.titleNano Researchpt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNameFélix Rodrigues
person.familyNameAndrade Jacinto
person.familyNameMoreira
person.familyNameda Rocha Costa
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.givenNameAna Carolina
person.givenNameTelma Maria
person.givenNameAndré Ferreira
person.givenNameElisabete Cristina
person.givenNameSónia Alexandra
person.givenNameIlídio
person.identifier1161643
person.identifierGX0L2QAAAAJ
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person.identifier.ciencia-id3D14-BE84-E5CD
person.identifier.ciencia-id2717-B57C-9AD7
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-idB314-4CF0-6633
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-5493-8331
person.identifier.orcid0000-0002-0135-2126
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-0490-0095
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id57202076016
person.identifier.scopus-author-id57205459390
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id55805850100
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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