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Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases

2018-05-13Journal article Open access
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dc.contributor.authorMesquita, Joana
dc.contributor.authorSousa, João Paulo Castro De
dc.contributor.authorPereira, Sara Vaz
dc.contributor.authorNeves, Arminda
dc.contributor.authorPassarinha, L A
dc.contributor.authorTomaz, C. T.
dc.date.accessioned2020-02-10T10:25:43Z
dc.date.available2021-05-13T00:30:13Z
dc.date.issued2018-05-13
dc.description.abstractVEGF-A and VEGF-B are proangiogenic and key regulating factors for blood vessel growth. This study aims to compare VEGF-A and VEGF-B levels in the serum and vitreous of patients with neovascular pathology versus non-neovascular pathology. Our findings showed vitreous VEGF-A and VEGF-B levels increased in patients with neovascular disease, with higher levels of VEGF-A compared to VEGF-B (p ≤ .05). In the diabetic retinopathy (DR) group, higher vitreous VEGF-A or VEGF-B were found in proliferative diabetic retinopathy (PDR) than in non-PDR. The strong correlation between VEGF-A and VEGF-B demonstrates a simultaneous pathological increase of cytokines (p < .001), suggesting besides VEGF-A, VEGF-B is another contributor to ocular pathologies involving angiogenesis. There was no correlation between vitreous and serum VEGF-A or VEGF-B; however, a correlation between vitreous (VEGF-A or VEGF-B) and macular volume (p < .05) in DR patients was found. Targeting VEGF-A and VEGF-B in macular and retinal vascular diseases, involving neovascularization, may improve treatment outcomes.pt_PT
dc.description.sponsorshipPOCI-01-0145-FEDER-007491pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/08977194.2018.1477140pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/9160
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.subjectNeovascularization, Pathologicpt_PT
dc.subjectRetinal Diseasespt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectVascular Endothelial Growth Factor Apt_PT
dc.subjectVascular Endothelial Growth Factor Bpt_PT
dc.subjectVitreous Bodypt_PT
dc.subjectELISApt_PT
dc.titleEvaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.citation.endPage57pt_PT
oaire.citation.issue1-2pt_PT
oaire.citation.startPage48pt_PT
oaire.citation.titleGrowth Factorspt_PT
oaire.citation.volume36pt_PT
oaire.fundingStream5876
person.familyNameMesquita
person.familyNameCastro de Sousa
person.familyNameVaz-Pereira
person.familyNamePaulino Passarinha
person.familyNameTomaz
person.givenNameJoana
person.givenNameJoão Paulo
person.givenNameSara
person.givenNameLuís António
person.givenNameCândida
person.identifierhttps://www.researchgate.net/profile/Luis_Passarinha
person.identifier2198714
person.identifier.ciencia-idD81B-D3DE-23D2
person.identifier.ciencia-id621B-74BF-F9A7
person.identifier.ciencia-idFE13-0C44-13D1
person.identifier.orcid0000-0003-0667-0809
person.identifier.orcid0000-0002-0025-1841
person.identifier.orcid0000-0001-6125-5486
person.identifier.orcid0000-0001-6910-7576
person.identifier.orcid0000-0002-0927-2331
person.identifier.ridP-8249-2017
person.identifier.ridF-9367-2014
person.identifier.scopus-author-id56262249200
person.identifier.scopus-author-id55820663800
person.identifier.scopus-author-id12445439600
person.identifier.scopus-author-id7004546303
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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