Repository logo
 
Publication

Biofunctionalization of electrospun poly(caprolactone) fibers with Maillard reaction products for wound dressing applications

2018-08-03Journal article Restricted access
Simple item page
dc.contributor.authorSimões, Déborah
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2018-08-23T09:00:45Z
dc.date.available2018-08-23T09:00:45Z
dc.date.issued2018-08-03
dc.description.abstractBacterial colonization of open skin wounds can interfere with the healing process, contributing to an increase in the severity of the wound. To overcome such drawback, wound dressings with an improved bactericidal activity have been developed or are currently under development. Herein, poly(caprolactone) (PCL) nanofibrous membranes functionalized with biosynthesized Maillard reaction products (MRPs) were produced using an electrospinning apparatus and their properties (chemical, morphological, mechanical and biological) analyzed in order to evaluate their suitability for being used as wound dressings. The functionalization of PCL nanofibers with MRPs allowed the production of membranes with the mechanical, wettability and porosity features required for wound exudate absorption as well as nutrients and gas exchange. Furthermore, MRPs-modified PCL membranes were also able to inhibit Staphylococcus aureus and Pseudomonas aeruginosa growth, without inducing any cytotoxic effect to human fibroblasts. These findings support the potential use of the produced membranes in the healing process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSimões, D., Miguel, S.P., Correia, I.J. (2018) "Biofunctionalization of electrospun Poly(caprolactone) fibers with Maillard Reaction Products for wound dressing applications", Reactive and Functional Polymers, Vol. 131, 191-202.pt_PT
dc.identifier.doi10.1016/j.reactfunctpolym.2018.07.021pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/5680
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHealth Sciences Research Centre
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1381514818305595pt_PT
dc.subjectAntimicrobial wound dressingpt_PT
dc.subjectElectrospinningpt_PT
dc.subjectMaillard reaction productspt_PT
dc.subjectPoly(caprolactone)pt_PT
dc.subjectSkin infectionpt_PT
dc.titleBiofunctionalization of electrospun poly(caprolactone) fibers with Maillard reaction products for wound dressing applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.endPage202pt_PT
oaire.citation.startPage191pt_PT
oaire.citation.titleReactive and Functional Polymerspt_PT
oaire.citation.volume131pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.givenNameSónia Alexandra
person.givenNameIlídio
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3956033a-4abf-439b-a4fd-25c5bd9d8e7a
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication.latestForDiscovery3956033a-4abf-439b-a4fd-25c5bd9d8e7a
relation.isProjectOfPublication1bea56d9-b91c-42af-a6d6-8004792eaac0
relation.isProjectOfPublication88d6f284-662c-44d7-afbd-e358ecd230f5
relation.isProjectOfPublication.latestForDiscovery1bea56d9-b91c-42af-a6d6-8004792eaac0

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2018 Simoes RFP.pdf
Size:
4.25 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito