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Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma

2015-12Journal article Restricted access
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dc.contributor.authorMamede, Ana Catarina Manjolinha
dc.contributor.authorGuerra, S
dc.contributor.authorLaranjo, Marta
dc.contributor.authorCarvalho, Maria J
dc.contributor.authorOliveira, R C
dc.contributor.authorGonçalves, A C
dc.contributor.authorAlves, R
dc.contributor.authorCastro, L Prado
dc.contributor.authorRibeiro, A B Sarmento
dc.contributor.authorMoura, P
dc.contributor.authorAbrantes, Ana M
dc.contributor.authorMaia, C J
dc.contributor.authorBotelho, M F
dc.date.accessioned2019-12-04T17:34:24Z
dc.date.available2019-12-04T17:34:24Z
dc.date.issued2015-12
dc.description.abstractHepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this reason, it is essential to invest in new therapies for this type of cancer. Our team already proved that human amniotic membrane (hAM) is able to inhibit the metabolic activity of several human cancer cell lines, including HCC cell lines. Taking into account the previously performed work, this experimental study aimed to investigate the pathways by which hAM protein extracts (hAMPEs) act on HCC. Our results showed that hAMPE reduce the metabolic activity, protein content and DNA content in a dose- and time-dependent manner in all HCC cell lines. This therapy presents selective cytotoxicity, since it was not able to inhibit a non-tumorigenic human cell line. In addition, hAMPE induced cell morphology alterations in all HCC cell lines, but death type is cell line dependent, as proved by in vitro and in vivo studies. In conclusion, hAMPE have a promising role in HCC therapy, since it is capable of inducing HCC cytotoxicity and cell death.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12032-015-0702-zpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7668
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHuman amniotic membranept_PT
dc.subjectHepatocellular carcinomapt_PT
dc.subjectProtein extractspt_PT
dc.subjecthAMPEpt_PT
dc.subjectCytotoxicitypt_PT
dc.titleSelective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73649%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FSINTD%2F60068%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FUI3282%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FNEU%2F04539%2F2013/PT
oaire.citation.conferencePlaceNorthwood, London, Englandpt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage257pt_PT
oaire.citation.titleMedical Oncologypt_PT
oaire.citation.volume32pt_PT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameLaranjo
person.familyNameCarvalho
person.familyNameAbrantes
person.familyNameMaia Baptista
person.familyNameBotelho
person.givenNameMarta
person.givenNameMaria J
person.givenNameAna M
person.givenNameCláudio Jorge
person.givenNameMaria Filomena
person.identifierI-6040-2012
person.identifier2085222
person.identifierR-000-10V
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierR-000-BFD
person.identifier.ciencia-id861A-EEAC-70E0
person.identifier.ciencia-id2B1C-C120-B274
person.identifier.ciencia-id7818-2E25-9410
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idD716-3387-EAC1
person.identifier.orcid0000-0002-3900-5592
person.identifier.orcid0000-0001-6819-927X
person.identifier.orcid0000-0003-4185-7871
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-7202-1650
person.identifier.ridG-6913-2018
person.identifier.ridG-1860-2011
person.identifier.scopus-author-id7801545833
person.identifier.scopus-author-id55440132400
person.identifier.scopus-author-id26029747600
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7005751167
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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