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Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma

2015-12Artigo científico Acesso restrito
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dc.contributor.authorMamede, AC
dc.contributor.authorGuerra, S
dc.contributor.authorLaranjo, Marta
dc.contributor.authorCarvalho, Maria J
dc.contributor.authorOliveira, R C
dc.contributor.authorGonçalves, A C
dc.contributor.authorAlves, R
dc.contributor.authorCastro, L Prado
dc.contributor.authorRibeiro, A B Sarmento
dc.contributor.authorMoura, P
dc.contributor.authorAbrantes, Ana M
dc.contributor.authorMaia, C J
dc.contributor.authorBotelho, M F
dc.date.accessioned2019-12-04T17:34:24Z
dc.date.available2019-12-04T17:34:24Z
dc.date.issued2015-12
dc.description.abstractHepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this reason, it is essential to invest in new therapies for this type of cancer. Our team already proved that human amniotic membrane (hAM) is able to inhibit the metabolic activity of several human cancer cell lines, including HCC cell lines. Taking into account the previously performed work, this experimental study aimed to investigate the pathways by which hAM protein extracts (hAMPEs) act on HCC. Our results showed that hAMPE reduce the metabolic activity, protein content and DNA content in a dose- and time-dependent manner in all HCC cell lines. This therapy presents selective cytotoxicity, since it was not able to inhibit a non-tumorigenic human cell line. In addition, hAMPE induced cell morphology alterations in all HCC cell lines, but death type is cell line dependent, as proved by in vitro and in vivo studies. In conclusion, hAMPE have a promising role in HCC therapy, since it is capable of inducing HCC cytotoxicity and cell death.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s12032-015-0702-zpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7668
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationBolsa de Doutoramento FCT - Estudo da membrana amniótica humana e o seu efeito em linhagens celulares de cancro, particularmente em carcinoma hepatocelular (cancro do fígado) [SFRH/BD/73649/2010]
dc.relationBolsa de investigação FCT: Células tumorais do cancro do endométrio: caracterização, resposta à terapêutica e padrão de metastização in vivo [SFRH/SINTD/60068/2009]
dc.relationStrategic project UI 3282 [PEst-C/SAU/UI3282/2013]
dc.relationTherapy 2 –Stem cell biotechnology, Strategic project of the consortium CNC.IBILI [UID/NEU/04539/2013]
dc.subjectHuman amniotic membranept_PT
dc.subjectHepatocellular carcinomapt_PT
dc.subjectProtein extractspt_PT
dc.subjecthAMPEpt_PT
dc.subjectCytotoxicitypt_PT
dc.titleSelective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/73649/2010
oaire.awardNumberSFRH/SINTD/60068/2009
oaire.awardNumberPEst-C/SAU/UI3282/2013
oaire.awardNumberUID/NEU/04539/2013
oaire.awardTitleBolsa de Doutoramento FCT - Estudo da membrana amniótica humana e o seu efeito em linhagens celulares de cancro, particularmente em carcinoma hepatocelular (cancro do fígado) [SFRH/BD/73649/2010]
oaire.awardTitleBolsa de investigação FCT: Células tumorais do cancro do endométrio: caracterização, resposta à terapêutica e padrão de metastização in vivo [SFRH/SINTD/60068/2009]
oaire.awardTitleStrategic project UI 3282 [PEst-C/SAU/UI3282/2013]
oaire.awardTitleTherapy 2 –Stem cell biotechnology, Strategic project of the consortium CNC.IBILI [UID/NEU/04539/2013]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73649%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FSINTD%2F60068%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FSAU%2FUI3282%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FNEU%2F04539%2F2013/PT
oaire.citation.conferencePlaceNorthwood, London, Englandpt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage257pt_PT
oaire.citation.titleMedical Oncologypt_PT
oaire.citation.volume32pt_PT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
oaire.fundingStreamCOMPETE
oaire.fundingStream5876
person.familyNameMamede
person.familyNameLaranjo
person.familyNameCarvalho
person.familyNameAbrantes
person.familyNameMaia Baptista
person.familyNameBotelho
person.givenNameAna Catarina Manjolinha
person.givenNameMarta
person.givenNameMaria J
person.givenNameAna M
person.givenNameCláudio Jorge
person.givenNameMaria Filomena
person.identifierI-6040-2012
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person.identifierR-000-10V
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierR-000-BFD
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person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-idD716-3387-EAC1
person.identifier.gsidClNSflIAAAAJ&hl
person.identifier.orcid0000-0002-6149-3190
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person.identifier.orcid0000-0003-4185-7871
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-7202-1650
person.identifier.ridG-6913-2018
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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