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The impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trials

2024-02-29Journal article Open access
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dc.contributor.authorKujawska, Agnieszka
dc.contributor.authorBromage, Sabri
dc.contributor.authorSimões, José Augusto Rodrigues
dc.contributor.authorZupkauskiene, Jurate
dc.contributor.authorMcMahon, Nicholas
dc.contributor.authorZalewski, Pawel
dc.contributor.authorKujawski, Sławomir
dc.date.accessioned2024-03-20T14:49:08Z
dc.date.available2024-03-20T14:49:08Z
dc.date.issued2024-02-29
dc.description.abstractPurpose The prevalence of hypertension (HTN) increases with age and there is a need for effective, evidence-based treatments for HTN among older adults. The objective of this study was to perform a network meta-analysis to evaluate the effectiveness of different forms of nutritional supplementation on reducing blood pressure in older adults. Methods A systematic review using PubMed and Clinical Key was performed to identify randomized controlled trials (RCTs) evaluating the effects of dietary supplements on blood pressure in adults older than 65 years of age. Network meta-analysis (NMA) was used to compare and rank the effects of different supplements on systolic (sBP), diastolic (dBP), and mean (mBP) blood pressure. Supplements were ranked according to P score. Meta-regressions were conducted to examine whether treatment effects were moderated by baseline BP and supplementation duration. Findings We identified 144 relevant studies in the literature, twelve of which met criteria for inclusion in NMA. The included studies were published between 2003 and 2022. In reducing sBP, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), inorganic nitrates, tart cherry juice, and vitamin D supplementation were more effective than placebo, and the effect of tart cherry juice outranked that of vitamin D, vitamin E, and vitamin K2. In reducing dBP, inorganic nitrates, DHA and EPA, protein, resveratrol, and vitamin D supplementation were more effective than placebo, and the effect of resveratrol outranked that of tart cherry juice, vitamin D, vitamin E, and vitamin K2. However, the effects of tart cherry juice on sBP and resveratrol on dPB were smaller than the pooled effect of placebo, and none of the pairwise differences between the effects of examined supplements were statistically significant. Caution is needed when interpreting these results given concerns about the risk of bias assessed in seven of the twelve studies included in this analysis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAgnieszka Kujawska, Sabri Bromage, Jose Augusto Simoes, Jūratė Zupkauskienė, Nicholas McMahon, Paweł Zalewski, Sławomir Kujawski. The impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trials. Heliyon. 2024; 10(4):e25615. https://doi.org/10.1016/j.heliyon.2024.e25615.pt_PT
dc.identifier.doi10.1016/j.heliyon.2024.e25615pt_PT
dc.identifier.issn2405-8440
dc.identifier.urihttp://hdl.handle.net/10400.6/14290
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier Ltdpt_PT
dc.relation.publisherversionhttps://www.cell.com/heliyon/fulltext/S2405-8440(24)01646-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844024016463%3Fshowall%3Dtrue#%20pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHypertensionpt_PT
dc.subjectOlder adultspt_PT
dc.subjectDietary supplementspt_PT
dc.subjectNutritional supplementationpt_PT
dc.subjectElderlypt_PT
dc.titleThe impact of dietary supplements on blood pressure in older adults: A network meta-analysis of randomized controlled trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPagee25615pt_PT
oaire.citation.titleHeliyonpt_PT
oaire.citation.volume10pt_PT
person.familyNameKujawska
person.familyNameBromage
person.familyNameRodrigues Simões
person.familyNameZupkauskiene
person.familyNameMcMahon
person.familyNameZalewski
person.familyNameKujawski
person.givenNameAgnieszka
person.givenNameSabri
person.givenNameJosé Augusto
person.givenNameJurate
person.givenNameNicholas
person.givenNamePawel
person.givenNameSławomir
person.identifier1706598
person.identifier795950
person.identifierL-4695-2016
person.identifier.ciencia-idE419-CED2-38BA
person.identifier.orcid0000-0001-6022-8478
person.identifier.orcid0000-0002-6552-4871
person.identifier.orcid0000-0003-2264-7086
person.identifier.orcid0000-0001-7031-0731
person.identifier.orcid0000-0002-7195-6005
person.identifier.orcid0000-0001-8453-7785
person.identifier.orcid0000-0001-5186-5037
person.identifier.ridH-6676-2016
person.identifier.ridT-5073-2017
person.identifier.scopus-author-id57191191130
person.identifier.scopus-author-id36896116500
person.identifier.scopus-author-id57201666599
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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