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Aerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung delivery

2017-01-19Journal article Restricted access
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dc.contributor.authorSilva, A. Sofia
dc.contributor.authorSousa, Ana M. L.
dc.contributor.authorCabral, Renato
dc.contributor.authorSilva, Marta
dc.contributor.authorSequeira, Clarinda Costa
dc.contributor.authorMiguel, Sónia
dc.contributor.authorBonifácio, Vasco
dc.contributor.authorCasimiro, Teresa
dc.contributor.authorCorreia, I.J.
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-22T09:04:40Z
dc.date.available2018-03-22T09:04:40Z
dc.date.issued2017-01-19
dc.description.abstractFunctionalized gold nanoparticles (AuNPs) have been widely investigated as promising multifunctional nanosystems for the theragnosis of lung cancer, the most common and prominent cause of cancer death worldwide. Nevertheless, nanoparticles are not in appropriate sizes for an accurate deep lung delivery and the lack of locally and effective delivery of therapeutic biomolecules to the deep lungs is, in fact, the major cause of low therapeutic outcome. Herein we incorporate, for the first time, AuNPs into respirable microparticles. AuNPs were functionalized with biocompatible oligo(2-oxazoline)-based optically stable fluorescent coatings, and conjugated with a laminin peptide (YIGSR) for targeted lung cancer delivery. These POxylated AuNPs were then incorporated into a chitosan matrix by a clean process, supercritical CO2-assisted spray drying (SASD), yielding nano-in-micro clean ultrafine dry powder formulations. The engineered formulations present the adequate morphology and flowability to reach the deep lung, with aerodynamic sizes ranging 3.2–3.8 μm, and excellent fine particle fraction (FPF) (FPF of 47% for CHT-bearing targeted AuNPs). The optimal biodegradation and release profiles enabled a sustained and controlled release of the embedded nanoparticles, with enhanced cellular uptake, opening new prospects for future lung theragnosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. S., Sousa, A. M., Cabral, R. P., Correia, I. J., e Aguiar-Ricardo, A. (2017) “Aerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung delivery.” International Journal of Pharmaceutics, Vol.519 (1-2), pp.240-249pt_PT
dc.identifier.doi10.1016/j.ijpharm.2017.01.032pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4696
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationSmart porous particles for pulmonary drug and vaccine delivery
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationAEROSOLIZED GOLD-NANODEVICES FOR THERANOSTIC LUNG DELIVERY
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517317300327#!pt_PT
dc.subjectLung cancerpt_PT
dc.subjectDry powder formulationpt_PT
dc.subjectPulmonary deliverypt_PT
dc.subjectGold nanoparticlespt_PT
dc.subjectNano-in-micropt_PT
dc.subjectSupercritical CO2pt_PT
dc.subjectSpray dryingpt_PT
dc.titleAerosolizable gold nano-in-micro dry powder formulations for theragnosis and lung deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleSmart porous particles for pulmonary drug and vaccine delivery
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleAEROSOLIZED GOLD-NANODEVICES FOR THERANOSTIC LUNG DELIVERY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEQU-EQU%2F116097%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F51584%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00915%2F2014%2FCP1224%2FCT0002/PT
oaire.citation.endPage249pt_PT
oaire.citation.startPage240pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume519pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamInvestigador FCT
person.familyNameMatias da Silva
person.familyNameSousa
person.familyNameCabral
person.familyNameCosta Sequeira
person.familyNamePereira Miguel
person.familyNameBonifácio
person.familyNameCasimiro
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.givenNameAna Sofia
person.givenNameAna
person.givenNameRenato
person.givenNameClarinda
person.givenNameSónia Alexandra
person.givenNameVasco Daniel Bigas
person.givenNameTeresa
person.givenNameIlídio
person.givenNameAna
person.identifierGX0L2QAAAAJ
person.identifierbit.ly/google_scholar_bonifacio
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person.identifier.ciencia-idF610-7373-DC81
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person.identifier.orcid0000-0002-5388-1732
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person.identifier.ridC-3286-2011
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person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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