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Phytochemical Characterization, Bioactivities Evaluation and Synergistic Effect of Arbutus unedo and Crataegus monogyna Extracts with Amphotericin B

2020Journal article Restricted access
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dc.contributor.authorCoimbra, Alexandra
dc.contributor.authorLuís, Ângelo
dc.contributor.authorBatista, Maria Teresa
dc.contributor.authorFerreira, Susana
dc.contributor.authorDuarte, A. P.
dc.date.accessioned2020-09-09T09:12:26Z
dc.date.available2020-09-09T09:12:26Z
dc.date.issued2020
dc.description.abstractThe increased resistance to drugs by pathogens is a serious problem, with plants showing to be promising sources for the development of new drugs or the improvement of the effect of existing antimicrobial agents. Considering this, we aimed to evaluate the bioactivities of Arbutus unedo and Crataegus monogyna. Thus, the leaves were first extracted with methanol and then fractionated with different solvents. Phenolic compound profiles were assessed by HPLC-PDA-MSn and the antioxidant activity was evaluated using DPPH method and β-carotene bleaching assay. The antimicrobial activity of extracts was tested against several microorganisms. A. unedo contained mainly galloyl esters, hydrolysable tannins, and flavonoids, while in C. monogyna, 5-caffeoylquinic acid and flavonoids were the most representative polyphenols. Crude extracts showed antioxidant activity and the extracts and fractions displayed a weak antibacterial activity; however inhibiting the growth of Candida tropicalis and C. lusitaniae to which A. unedo extract showed higher activity. Most of the extracts and fractions demonstrated synergistic or additive interactions with amphotericin B against Candida spp. Therefore, the present study revealed significant bioactive properties of the extracts and fractions of A. unedo and C. monogyna, such as antioxidant and antifungal activities.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00284-020-02125-wpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10418
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.titlePhytochemical Characterization, Bioactivities Evaluation and Synergistic Effect of Arbutus unedo and Crataegus monogyna Extracts with Amphotericin Bpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2019/PT
oaire.citation.endPage2154pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2143pt_PT
oaire.citation.titleCurrent Microbiologypt_PT
oaire.citation.volume77pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCoimbra
person.familyNameSantos Luís
person.familyNameBatista
person.familyNameFerreira
person.familyNameDuarte
person.givenNameAlexandra
person.givenNameÂngelo Filipe
person.givenNameMaria Teresa
person.givenNameSusana
person.givenNameAna Paula
person.identifier1255684
person.identifier.ciencia-id5E13-71C0-6CDC
person.identifier.ciencia-id3D14-798B-65D3
person.identifier.ciencia-idF718-3569-E911
person.identifier.ciencia-idBC15-D376-80FE
person.identifier.orcid0000-0003-0652-4342
person.identifier.orcid0000-0003-0712-6522
person.identifier.orcid0000-0003-4183-6202
person.identifier.orcid0000-0001-8308-2862
person.identifier.orcid0000-0003-3333-5977
person.identifier.ridA-6810-2016
person.identifier.ridB-5904-2009
person.identifier.scopus-author-id57217294397
person.identifier.scopus-author-id7005481959
person.identifier.scopus-author-id34874668400
person.identifier.scopus-author-id7102602131
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicação.pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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