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Incorporation of antimicrobial peptides on functionalized cotton gauzes for medical applications

2015Journal article Open access
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dc.contributor.authorGomes, Ana
dc.contributor.authorMano, João F.
dc.contributor.authorQueiroz, João
dc.contributor.authorGouveia, Isabel C.
dc.date.accessioned2019-11-04T14:30:09Z
dc.date.available2019-11-04T14:30:09Z
dc.date.issued2015
dc.description.abstractA large group of low molecular weight natural compounds that exhibit antimicrobial activity has been isolated from animals and plants during the past two decades. Among them, peptides are the most widespread resulting in a new generation of antimicrobial agents with higher specific activity. In the present study we have developed a new strategy to obtain antimicrobial wound-dressings based on the incorporation of antimicrobial peptides into polyelectrolyte multilayer films built by the alternate deposition of polycation (chitosan) and polyanion (alginic acid sodium salt) over cotton gauzes. Energy dispersive X ray microanalysis technique was used to determine if antimicrobial peptides penetrated within the films. FTIR analysis was performed to assess the chemical linkages, and antimicrobial assays were performed with two strains: Staphylococcus aureus (Gram-positive bacterium) and Klebsiella pneumonia (Gram-negative bacterium). Results showed that all antimicrobial peptides used in this work have provided a higher antimicrobial effect (in the range of 4 log-6 log reduction) for both microorganisms, in comparison with the controls, and are non-cytotoxic to normal human dermal fibroblasts at the concentrations tested.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.carbpol.2015.03.089pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7497
dc.language.isoengpt_PT
dc.relationSkin2Tex Old peptides with new faces: A new strategy to develop non-toxic antimicrobial textiles for healthcare applications.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobial peptidespt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectCys-LC-LL-37pt_PT
dc.subjectDermaseptinpt_PT
dc.subjecthBD-1humanpt_PT
dc.subjectMagainin 1pt_PT
dc.subjectWound-dressingpt_PT
dc.subjectβ-Defensin-1pt_PT
dc.titleIncorporation of antimicrobial peptides on functionalized cotton gauzes for medical applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSkin2Tex Old peptides with new faces: A new strategy to develop non-toxic antimicrobial textiles for healthcare applications.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F113671%2F2009/PT
oaire.citation.endPage461pt_PT
oaire.citation.startPage451pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume127pt_PT
oaire.fundingStream5876-PPCDTI
person.familyNameGomes
person.familyNameMano
person.familyNameQueiroz
person.familyNameGouveia
person.givenNameAna Paula
person.givenNameJoão
person.givenNameJoão
person.givenNameIsabel Cristina
person.identifier626131
person.identifier.ciencia-id221C-606F-5072
person.identifier.ciencia-id931E-B66D-E341
person.identifier.ciencia-id5711-86D0-A54B
person.identifier.orcid0000-0002-3332-834X
person.identifier.orcid0000-0002-2342-3765
person.identifier.orcid0000-0002-3096-8325
person.identifier.orcid0000-0003-3290-9529
person.identifier.ridA-4418-2009
person.identifier.ridL-3104-2014
person.identifier.ridK-1651-2014
person.identifier.scopus-author-id26643558900
person.identifier.scopus-author-id7003705645
person.identifier.scopus-author-id24328741500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationd8f53353-948c-4b3f-b85c-b114e05429a7
relation.isAuthorOfPublicationc798c033-c160-4f99-a8ad-04416923943f
relation.isAuthorOfPublicationa2024ec6-6edb-47e5-b8a0-594066a5036c
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