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Injectable in situ forming thermo-responsive graphene based hydrogels for cancer chemo-photothermal therapy and NIR light-enhanced antibacterial applications

2020-07-24Journal article Open access
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dc.contributor.authorSousa, Rita Lima
dc.contributor.authorDiogo, Duarte de Melo
dc.contributor.authorAlves, Cátia
dc.contributor.authorCabral, Cátia S. D.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorMendonça, António
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2020-10-15T16:25:42Z
dc.date.available2022-10-15T00:30:22Z
dc.date.issued2020-07-24
dc.description.abstractFunctionalized graphene oxide (GO) and reduced GO (rGO) based nanomaterials hold a great potential for cancer photothermal therapy. However, their systemic administration has been associated with an accelerated blood clearance and/or with suboptimal tumor uptake. To address these limitations, the local delivery of GO/rGO to the tumor site by 3D matrices arises as a promising strategy. In this work, injectable chitosan-agarose in situ forming thermo-responsive hydrogels incorporating GO (thermogel-GO) or rGO (thermogel-rGO) were prepared for the first time. The hydrogels displayed suitable injectability and gelation time, as well as good physicochemical properties and cytocompatibility. When irradiated with near infrared (NIR) light, the thermogel-rGO produced a 3.8-times higher temperature increase than thermogel-GO, thus decreasing breast cancer cells' viability to 60%. By incorporating an optimized molar ratio of the Doxorubicin:Ibuprofen combination on thermogel-rGO, this formulation mediated a chemo-photothermal effect that further diminished cancer cells' viability to 34%. In addition, the hydrogels' antibacterial activity was further enhanced upon NIR laser irradiation, which is an important feature considering the possible risk of infection at the site of administration. Overall, thermogel-rGO is a promising injectable in situ forming hydrogel for combinatorial chemo-photothermal therapy of breast cancer cells and NIR light enhanced antibacterial applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.msec.2020.111294pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/10455
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
dc.relationInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
dc.subjectAntibacterial activitypt_PT
dc.subjectCancerpt_PT
dc.subjectChemo-photothermal therapypt_PT
dc.subjectGraphene family nanomaterialspt_PT
dc.subjectInjectable hydrogelpt_PT
dc.titleInjectable in situ forming thermo-responsive graphene based hydrogels for cancer chemo-photothermal therapy and NIR light-enhanced antibacterial applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a responsive multi-layer microneedle patch for the sequential PTT/PDT and immunotherapy of invasive breast cancer
oaire.awardTitleInjectable in situ forming graphene-based hydrogels for double immune checkpoint inhibitor photothermal therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F145386%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F144922%2F2019/PT
oaire.citation.conferencePlaceNetherlandspt_PT
oaire.citation.startPage111294pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume117pt_PT
oaire.fundingStreamPOR_CENTRO
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
person.familyNameSousa
person.familyNameMiguel de Melo Diogo
person.familyNameAlves
person.familyNameCabral
person.familyNamePereira Miguel
person.familyNameMendonça
person.familyNameJoaquim Sobreira Correia
person.givenNameAna Rita Lima
person.givenNameDuarte
person.givenNameCátia Gomes
person.givenNameCátia Solange Duarte
person.givenNameSónia Alexandra
person.givenNameAntónio
person.givenNameIlídio
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person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0003-4764-1967
person.identifier.orcid0000-0001-9984-3603
person.identifier.orcid0000-0001-7066-3051
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridB-1125-2019
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id57201215315
person.identifier.scopus-author-id56266511300
person.identifier.scopus-author-id57201213407
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person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctO copyright foi cedido à editorapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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