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Development of 2-(dimethylamino)ethyl methacrylate-based molecular recognition devices for controlled drug delivery using supercritical fluid technology

2011-06-20Journal article Restricted access
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dc.contributor.authorSilva, Mara da
dc.contributor.authorViveiros, Raquel
dc.contributor.authorMorgado, Patrícia I.
dc.contributor.authorRicardo, Ana Aguiar
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorCasimiro, Teresa
dc.date.accessioned2018-03-19T10:56:04Z
dc.date.available2018-03-19T10:56:04Z
dc.date.issued2011-06-20
dc.description.abstractThis work reports the development of a novel potential body-friendly oral drug delivery system, which consists of a biocompatible molecularly imprinted polymer (MIP), with pH sensitive character and low cross-linking degree (20.2 wt%), synthesized and processed in supercritical carbon dioxide. The MIP is synthesized using 2-(dimethylamino)ethyl methacrylate (DMAEMA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker, and ibuprofen as molecular recognition template. The imprinted matrix was able to show a higher affinity towards ibuprofen than its corresponding non-imprinted polymer (NIP) meaning that the molecular imprinting in scCO2 was efficient even using a low crosslinking degree. MIP showed a significant molecular recognition towards the template, presenting higher drug uptake ability in the supercritical impregnation step, loading 33.1 wt% of ibuprofen compared to only 10.2 wt% for the NIP polymer. In vitro drug release experiments, simulating an oral administration, showed different release profiles at pH 2.2 and pH 7.4. Zeta potential measurements were performed to both MIP and NIP showing that the imprinting process has a significant influence on the charge of the polymeric particles. Cytotoxicity assays performed with human colorectal carcinoma-derived Caco-2 cells demonstrated that the polymers are biocompatible and could be potentially used in drug delivery applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationda Silva, M.S., Viveiros, R., Morgado, P.I., Aguiar-Ricardo, R., Correia, I.J. e Casimiro, T. (2011) “Development of 2-(dimethylamino)ethyl methacrylate-based molecular recognition devices for controlled drug delivery using supercritical fluid technology”, International Journal of Pharmaceutics, Vol. 416(1), pp. 61-68pt_PT
dc.identifier.doi10.1016/j.ijpharm.2011.06.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4630
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation“Green” production of cyclodextrin-based matrixes using supercritical carbon dioxide
dc.relationPREPARATION OF MOLECULARLY IMPRINTED POLYMERS FOR DRUG DELIVERY USING SUPERCRITICAL FLUID TECHNOLOGY
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517311005357#!pt_PT
dc.subjectSupercritical carbon dioxidept_PT
dc.subjectMolecular imprintingpt_PT
dc.subjectDrug deliverypt_PT
dc.subjectDMAEMApt_PT
dc.titleDevelopment of 2-(dimethylamino)ethyl methacrylate-based molecular recognition devices for controlled drug delivery using supercritical fluid technologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitle“Green” production of cyclodextrin-based matrixes using supercritical carbon dioxide
oaire.awardTitlePREPARATION OF MOLECULARLY IMPRINTED POLYMERS FOR DRUG DELIVERY USING SUPERCRITICAL FLUID TECHNOLOGY
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI%2F66086%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QUI%2F102460%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-TME%2F103375%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F31085%2F2006/PT
oaire.citation.endPage68pt_PT
oaire.citation.startPage61pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume416pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameDa Cruz Morgado Ferreira
person.familyNameAguiar-Ricardo
person.familyNameJoaquim Sobreira Correia
person.familyNameCasimiro
person.givenNamePatrícia Isabel
person.givenNameAna
person.givenNameIlídio
person.givenNameTeresa
person.identifier239073
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idE71C-3D0E-821B
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-idC319-27F6-1C6B
person.identifier.orcid0000-0002-1005-9853
person.identifier.orcid0000-0002-2193-1440
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0001-9405-6221
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id6602194100
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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