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Regucalcin is expressed in rat mammary gland and prostate and down-regulated by 17beta-estradiol

2008-04Journal article Restricted access
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dc.contributor.authorMaia, C J
dc.contributor.authorSantos, Cecilia
dc.contributor.authorSchmitt, Fernando
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2019-10-03T15:30:37Z
dc.date.available2019-10-03T15:30:37Z
dc.date.issued2008-04
dc.description.abstractRegucalcin is involved in maintenance of calcium homeostasis due to the activation of Ca2+ pumping enzymes in the plasma membrane. It has a suppressive effect in cell proliferation, DNA and RNA synthesis, and may be associated with the abnormal cell division on tumor tissues. On the other hand both estrogens and Ca2+ are implicated in breast and prostate cancer but there are no studies focused on the expression of regucalcin in rat mammary gland or prostate. Furthermore, it is known that the expression of regucalcin in rat liver and kidney is regulated by 17beta-estradiol (E2). The aim of this study is to analyze if regucalcin is expressed in rat mammary gland and prostate and if it is regulated by E2 in these tissues. We demonstrated for the first time that regucalcin mRNA and protein are present in rat mammary gland and prostate by in situ hybridization and immunohistochemistry, respectively. Furthermore, we show by Real-time PCR that E2 down-regulates regucalcin expression in rat mammary gland and prostate.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s11010-007-9697-xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7218
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectRegucalcinpt_PT
dc.subjectSMP30pt_PT
dc.subjectCalciumpt_PT
dc.subjectMammary glandpt_PT
dc.subjectProstatept_PT
dc.subject17beta-estradiolpt_PT
dc.titleRegucalcin is expressed in rat mammary gland and prostate and down-regulated by 17beta-estradiolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage86pt_PT
oaire.citation.issue1-2pt_PT
oaire.citation.startPage81-6pt_PT
oaire.citation.volume311pt_PT
person.familyNameMaia Baptista
person.familyNameSANTOS
person.familyNameSchmitt
person.familyNameSocorro
person.givenNameCláudio Jorge
person.givenNameCecília Reis Alves
person.givenNameFernando
person.givenNameSílvia Cristina da Cruz Marques
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-id761A-7ED2-D68F
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0001-6074-7825
person.identifier.orcid0000-0003-1006-6946
person.identifier.orcid0000-0001-8181-488X
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7202545664
person.identifier.scopus-author-id23097994600
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1080c532-c737-4b60-bc44-1d18e3c877d7
relation.isAuthorOfPublication21e86061-71ea-4cfa-bc85-0fcd6e847911
relation.isAuthorOfPublication8dd07c9e-eb0d-4e4a-a8d1-2e3787e7f7bf
relation.isAuthorOfPublication1fb06949-0e6c-41a6-bb25-11885e7f0e9a
relation.isAuthorOfPublication.latestForDiscovery1080c532-c737-4b60-bc44-1d18e3c877d7

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