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The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease

2014-01Journal article Restricted access
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dc.contributor.authorMarques, Ricardo
dc.contributor.authorBaptista, Cláudio
dc.contributor.authorVaz, CV
dc.contributor.authorCorreia, Sara
dc.contributor.authorSocorro, Sílvia
dc.date.accessioned2019-11-28T17:15:25Z
dc.date.available2019-11-28T17:15:25Z
dc.date.issued2014-01
dc.description.abstractRegucalcin (RGN) is a calcium (Ca(2+))-binding protein widely expressed in vertebrate and invertebrate species, which is also known as senescence marker protein 30, due to its molecular weight (33 kDa) and a characteristically diminished expression with the aging process. RGN regulates intracellular Ca(2+) homeostasis and the activity of several proteins involved in intracellular signalling pathways, namely, kinases, phosphatases, phosphodiesterase, nitric oxide synthase and proteases, which highlights its importance in cell biology. In addition, RGN has cytoprotective effects reducing intracellular levels of oxidative stress, also playing a role in the control of cell survival and apoptosis. Multiple factors have been identified regulating the cell levels of RGN transcripts and protein, and an altered expression pattern of this interesting protein has been found in cases of reproductive disorders, neurodegenerative diseases and cancer. Moreover, RGN is a serum-secreted protein, and its levels have been correlated with the stage of disease, which strongly suggests the usefulness of this protein as a potential biomarker for monitoring disease onset and progression. The present review aims to discuss the available information concerning RGN expression and function in distinct cell types and tissues, integrating cellular and molecular mechanisms in the context of normal and pathological conditions. Insight into the cellular actions of RGN will be a key step towards deepening the knowledge of the biology of several human diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s00018-013-1323-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/7641
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationStrategic Project - UI 709 - 2011-2012
dc.relationROLE OF REGUCALCIN IN BREAST CELLS PROLIFERATION AND TUMOR DEVELOPMENT
dc.subjectRegucalcinpt_PT
dc.subjectSMP30pt_PT
dc.subjectCalciumpt_PT
dc.subjectApoptosispt_PT
dc.subjectOxidative stresspt_PT
dc.subjectCell proliferationpt_PT
dc.titleThe diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 709 - 2011-2012
oaire.awardTitleROLE OF REGUCALCIN IN BREAST CELLS PROLIFERATION AND TUMOR DEVELOPMENT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FUI0709%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F66875%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70316%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F60945%2F2009/PT
oaire.citation.endPage111pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage93pt_PT
oaire.citation.titleCellular and Molecular Life Sciencespt_PT
oaire.citation.volume71pt_PT
oaire.fundingStream6820 - DCRRNI ID
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameMaia Baptista
person.familyNameVaz
person.familyNameCorreia
person.familyNameSocorro
person.givenNameCláudio Jorge
person.givenNameCátia
person.givenNameSara
person.givenNameSílvia Cristina da Cruz Marques
person.identifierhttps://scholar.google.pt/citations?user=hFKOd_QAAAAJ&hl=pt-PT&oi=ao
person.identifierhttps://scholar.google.pt/citations?user=PA3L_h8AAAAJ&hl=pt-PT
person.identifier.ciencia-id5115-FCBD-A31F
person.identifier.ciencia-id1C1D-F91F-D937
person.identifier.ciencia-id7518-7FBC-A42F
person.identifier.ciencia-idAB17-5C25-1F2C
person.identifier.orcid0000-0002-5658-5445
person.identifier.orcid0000-0002-7720-4234
person.identifier.orcid0000-0001-9199-8360
person.identifier.orcid0000-0001-8181-488X
person.identifier.scopus-author-id23097426600
person.identifier.scopus-author-id7004157751
person.identifier.scopus-author-id23097994600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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