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Alginate based scaffolds for bone tissue engineering

2012-08-12Journal article Restricted access
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dc.contributor.authorValente, Joana
dc.contributor.authorValente, Tiago António Martins
dc.contributor.authorAlves, Patrícia
dc.contributor.authorFerreira, Paula
dc.contributor.authorSilva, Abílio
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2018-03-19T14:20:44Z
dc.date.available2018-03-19T14:20:44Z
dc.date.issued2012-08-12
dc.description.abstractThe design and production of scaffolds for bone tissue regeneration is yet unable to completely reproduce the native bone properties. In the present study new alginate microparticle and microfiber aggregated scaffolds were produced to be applied in this area of regenerative medicine. The scaffolds' mechanical properties were characterized by thermo mechanical assays. Their morphological characteristics were evaluated by isothermal nitrogen adsorption and scanning electron microscopy. The density of both types of scaffolds was determined by helium pycnometry and mercury intrusion porosimetry. Furthermore, scaffolds' cytotoxic profiles were evaluated in vitro by seeding human osteoblast cells in their presence. The results obtained showed that scaffolds have good mechanical and morphological properties compatible with their application as bone substitutes. Moreover, scaffold's biocompatibility was confirmed by the observation of cell adhesion and proliferation after 5 days of being seeded in their presence and by non-radioactive assays.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationValente, J., Valente, T.A.M., Alves, P., Ferreira, P., Silva, A.P. e Correia, I.J. (2012) "Alginate based scaffolds for bone tissue engineering", Materials Science & Engineering C - Materials for Biological Applications, Vol. 32(8), pp. 2596-2603pt_PT
dc.identifier.doi10.1016/j.msec.2012.08.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4634
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0928493112003669#!pt_PT
dc.subject3D scaffoldspt_PT
dc.subjectBiocompatibilitypt_PT
dc.subjectBiomaterialspt_PT
dc.subjectBone Tissue Engineeringpt_PT
dc.subjectIn vitro studiespt_PT
dc.titleAlginate based scaffolds for bone tissue engineeringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEME-TME%2F103375%2F2008/PT
oaire.citation.endPage2603pt_PT
oaire.citation.startPage2596pt_PT
oaire.citation.volume32pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameValente
person.familyNameAlves
person.familyNameCristina Nunes Ferreira Calvinho
person.familyNameSilva
person.familyNameJoaquim Sobreira Correia
person.givenNameJoana
person.givenNamePatrícia
person.givenNamePaula
person.givenNameAbilio
person.givenNameIlídio
person.identifierVABrK9AAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id7515-7468-212D
person.identifier.ciencia-id341B-551C-19FD
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idD314-9C94-0B0F
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0002-2408-9762
person.identifier.orcid0000-0002-8943-8329
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0002-2100-7223
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-1004-2013
person.identifier.ridO-1474-2013
person.identifier.scopus-author-id12762379800
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id8540933900
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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