Repository logo
 
Publication

Nanogold POxylation: towards always-on fluorescent lung cancer targeting

2016-03-28Journal article Restricted access
Simple item page
dc.contributor.authorSilva, A. Sofia
dc.contributor.authorSilva, Marta
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorBonifácio, Vasco
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-21T11:48:50Z
dc.date.available2018-03-21T11:48:50Z
dc.date.issued2016-03-28
dc.description.abstractGold nanoparticles (GNPs) are one of most investigated nanomaterials for lung cancer diagnosis and therapy (theragnosis). For imaging purposes, GNPs are often tagged with fluorescent probes, but unfortunately the associated plasmon resonance effect leads to fluorescence self-quenching, thus precluding accurate localization. In this study, biocompatible GNPs targeted with a laminin fragment were successfully engineered using fluorescent oligo-oxazolines produced in supercritical carbon dioxide. The architecture and properties of the POxylated constructs were fully characterized and confocal laser scanning microscopy measurements demonstrated a higher cellular uptake into A549 lung cancer cells through an active targeting mechanism.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, A. S., Silva, M. C., Miguel, S. P., Bonifácio, V. D., Correia, I. J., e Aguiar-Ricardo, A. (2016) “Nanogold POxylation: towards always-on fluorescent lung cancer targeting.” RSC Advances, Vol.6 (40), pp. 33631-33635pt_PT
dc.identifier.doi10.1039/C6RA00532Bpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4682
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherRoyal Society of Chemistrypt_PT
dc.relation.publisherversionhttp://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra00532b#!divAbstractpt_PT
dc.subjectNanogoldpt_PT
dc.subjectPOxylationpt_PT
dc.subjectLung cancerpt_PT
dc.titleNanogold POxylation: towards always-on fluorescent lung cancer targetingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage33635pt_PT
oaire.citation.startPage33631pt_PT
oaire.citation.titleRSC Advancespt_PT
oaire.citation.volume6pt_PT
person.familyNameMatias da Silva
person.familyNamePereira Miguel
person.familyNameBonifácio
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.givenNameAna Sofia
person.givenNameSónia Alexandra
person.givenNameVasco Daniel Bigas
person.givenNameIlídio
person.givenNameAna
person.identifierGX0L2QAAAAJ
person.identifierbit.ly/google_scholar_bonifacio
person.identifierUMbJ1KMAAAAJ
person.identifier239073
person.identifier.ciencia-id7A1A-FEC8-7940
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idAE14-EB30-86A6
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-5388-1732
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-2349-8473
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd520a5a3-94a9-4b6d-ae60-4f7b1b2e4b71
relation.isAuthorOfPublication3956033a-4abf-439b-a4fd-25c5bd9d8e7a
relation.isAuthorOfPublication25a08d6b-f1f6-43e2-b59c-eb82fad34ef8
relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication11660e51-cb00-4f75-8ca1-274d0c47c590
relation.isAuthorOfPublication.latestForDiscovery3956033a-4abf-439b-a4fd-25c5bd9d8e7a

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
2016 Silva RSC advances.pdf
Size:
3.28 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FCS - DCM | Documentos por Auto-Depósito