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Ocular injectable formulation assessment for oxidized dextran-based hydrogels

2009-02-11Journal article Restricted access
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dc.contributor.authorMaia, João
dc.contributor.authorRibeiro, MP.
dc.contributor.authorVentura, Carla
dc.contributor.authorCarvalho, Rui
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorGil, Maria
dc.date.accessioned2018-03-16T14:13:05Z
dc.date.available2018-03-16T14:13:05Z
dc.date.issued2009-02-11
dc.description.abstractInitiator-free injectable hydrogels are very interesting for drug and/or cell delivery applications, since they can be administered in a minimally invasive way, and avoid the use of potentially harmful chemical initiators. In the current work, oxidized dextran crosslinked with adipic acid dihydrazide hydrogels were further characterized and tuned to produce formulations, with the aim of producing an injectable formulation for the possible treatment of posterior eye diseases. The gelation rate and the hydrogel dissolution profile were shown to be dependent on the balance between the degree of dextran oxidation, and the concentration of both components. For the in vitro studies, rabbit corneal endothelial cells were seeded on the hydrogels to assess cytotoxicity. Hydrogels prepared with low oxidized dextrans were able to promote cell adhesion and proliferation to confluence in just 24 h, while more highly oxidized samples promoted cell adhesion and proliferation, but without achieving confluence. Cell viability studies were performed using MTS assays to verify the non-cytotoxicity of hydrogels and their degradation byproducts, rendering these formulations attractive for further in vivo studies.pt_PT
dc.description.sponsorshipThis study was supported by Instituto de Investigação Interdisciplinar (financial support of J.M.: III/BIO/20/2005) and by the Portuguese Foundation for Science and Technology (in the form of fellowship to I.J.C.: SFRH/BPD/19776/2004).
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMaia, J., Ribeiro, M.P., Ventura, C., Carvalho, R.A., Correia, I.J. e Gil, M.H. (2009) “Ocular injectable formulation assessment for oxidized dextran-based hydrogels”, Acta Biomaterialia, Vol. 5(6), pp. 1948-55pt_PT
dc.identifier.doi10.1016/j.actbio.2009.02.008pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4623
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationESTUDOS ESTRUTURAIS, MECANÍSTICOS E FUNCIONAIS DE CANAIS DE CÁLCIO MEMBRANARES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1742706109000701pt_PT
dc.subjectInjectablept_PT
dc.subjectHydrogelpt_PT
dc.subjectOxidized dextranpt_PT
dc.subjectIn vitropt_PT
dc.subjectOcular deliverypt_PT
dc.titleOcular injectable formulation assessment for oxidized dextran-based hydrogelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleESTUDOS ESTRUTURAIS, MECANÍSTICOS E FUNCIONAIS DE CANAIS DE CÁLCIO MEMBRANARES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F19776%2F2004/PT
oaire.citation.endPage1955pt_PT
oaire.citation.startPage1948pt_PT
oaire.citation.titleActa Biomaterialiapt_PT
oaire.citation.volume5pt_PT
person.familyNameRibeiro
person.familyNameJoaquim Sobreira Correia
person.familyNameGil
person.givenNameMaximiano
person.givenNameIlídio
person.givenNameMaria Helena
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-idBD11-6497-FD37
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id0E10-A6F7-901B
person.identifier.orcid0000-0001-6357-8115
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0003-0657-7751
person.identifier.scopus-author-id26658759200
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicationf2c3e779-34a2-4309-950a-80687664c6ad
relation.isAuthorOfPublication676a8017-743a-4f22-93be-4915428f318d
relation.isAuthorOfPublication.latestForDiscovery676a8017-743a-4f22-93be-4915428f318d
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