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Ibuprofen loaded PVA/chitosan membranes: A highly efficient strategy towards an improved skin wound healing

2016-12-13Journal article Restricted access
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dc.contributor.authorMorgado, Patrícia I.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-21T16:52:36Z
dc.date.available2018-03-21T16:52:36Z
dc.date.issued2016-12-13
dc.description.abstractDuring wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclodextrins carriers were designed to customise the release profile of IBP from poly(vinyl alcohol)/chitosan (PVA/CS) dressings in order to promote a faster skin regeneration. The dressings were produced using supercritical carbon dioxide (scCO2)-assisted technique. In vitro IBP release studies showed that β-cyclodextrins allowed a controlled drug release from the hydrogels which is crucial for their application in wound management. Moreover, the in vivo assays revealed that the presence of PVA/CS membranes containing IBP-β-cyclodextrins carriers avoided scab formation and an excessive inflammation, enabling an earlier skin healing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMorgado, P. I., Miguel, S. P., Correia, I. J., Aguiar-Ricardo, A. (2017) “Ibuprofen loaded PVA/Chitosan membranes: a highly efficient strategy towards an improved skin wound healing.” Carbohydrate Polymers, Vol.159, pp.136-145pt_PT
dc.identifier.doi10.1016/j.carbpol.2016.12.029pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4692
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationHealth Sciences Research Centre
dc.relationSmart porous particles for pulmonary drug and vaccine delivery
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy
dc.relationDEVELOPMENT OF HYDROGELS LOADED WITH MICROPARTICLES CONTAINING CELLS AND BIOMOLECULES FOR SKIN REGENERATION
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0144861716313984pt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectComposite membranespt_PT
dc.subjectWound dressingspt_PT
dc.subjectIbuprofenpt_PT
dc.subjectIn vivo assayspt_PT
dc.subjectSupercritical carbon dioxidept_PT
dc.titleIbuprofen loaded PVA/chitosan membranes: A highly efficient strategy towards an improved skin wound healingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleSmart porous particles for pulmonary drug and vaccine delivery
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy
oaire.awardTitleDEVELOPMENT OF HYDROGELS LOADED WITH MICROPARTICLES CONTAINING CELLS AND BIOMOLECULES FOR SKIN REGENERATION
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.endPage145pt_PT
oaire.citation.startPage136pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume159pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876-PPCDTI
oaire.fundingStreamPOR_CENTRO
person.familyNameDa Cruz Morgado Ferreira
person.familyNamePereira Miguel
person.familyNameJoaquim Sobreira Correia
person.familyNameAguiar-Ricardo
person.givenNamePatrícia Isabel
person.givenNameSónia Alexandra
person.givenNameIlídio
person.givenNameAna
person.identifierGX0L2QAAAAJ
person.identifierUMbJ1KMAAAAJ
person.identifier239073
person.identifier.ciencia-idE71C-3D0E-821B
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-1005-9853
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctCopyright cedido à editora no momento da publicaçãopt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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