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Ibuprofen loaded PVA/chitosan membranes: A highly efficient strategy towards an improved skin wound healing

2016-12-13Artigo científico Acesso restrito
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dc.contributor.authorMorgado, Patrícia I.
dc.contributor.authorMiguel, Sónia P.
dc.contributor.authorCorreia, Ilídio Joaquim Sobreira
dc.contributor.authorRicardo, Ana Aguiar
dc.date.accessioned2018-03-21T16:52:36Z
dc.date.available2018-03-21T16:52:36Z
dc.date.issued2016-12-13
dc.description.abstractDuring wound healing, an early inflammation can cause an increase of the wound size and the healing process can be considerably belated if a disproportionate inflammatory response occurs. (S)-ibuprofen (IBP), a non-steroidal anti-inflammatory agent, has been used for muscle healing and to treat venous leg ulcers, but its effect in skin wound healing has not been thoroughly studied thus far. Herein, IBP-β-cyclodextrins carriers were designed to customise the release profile of IBP from poly(vinyl alcohol)/chitosan (PVA/CS) dressings in order to promote a faster skin regeneration. The dressings were produced using supercritical carbon dioxide (scCO2)-assisted technique. In vitro IBP release studies showed that β-cyclodextrins allowed a controlled drug release from the hydrogels which is crucial for their application in wound management. Moreover, the in vivo assays revealed that the presence of PVA/CS membranes containing IBP-β-cyclodextrins carriers avoided scab formation and an excessive inflammation, enabling an earlier skin healing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMorgado, P. I., Miguel, S. P., Correia, I. J., Aguiar-Ricardo, A. (2017) “Ibuprofen loaded PVA/Chitosan membranes: a highly efficient strategy towards an improved skin wound healing.” Carbohydrate Polymers, Vol.159, pp.136-145pt_PT
dc.identifier.doi10.1016/j.carbpol.2016.12.029pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/4692
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes [UID/QUI/50006/2013]
dc.relationHealth Sciences Research Centre [UID/Multi/00709/2013]
dc.relationSmart porous particles for pulmonary drug and vaccine delivery [PTDC/EQU-EQU/116097/2009]
dc.relationIsolation and Purification of Plasmid DNA for Cancer Therapy [PTDC/EBB-BIO/114320/2009]
dc.relationBolsa de Doutoramento FCT: Development of hydrogels loaded with microparticles containing cells and biomolecules for skin regeneration [SFRH/BD/80648/2011]
dc.relationBolsa de Doutoramento FCT: Development of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing [SFRH/BD/109563/2015]
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0144861716313984pt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectComposite membranespt_PT
dc.subjectWound dressingspt_PT
dc.subjectIbuprofenpt_PT
dc.subjectIn vivo assayspt_PT
dc.subjectSupercritical carbon dioxidept_PT
dc.titleIbuprofen loaded PVA/chitosan membranes: A highly efficient strategy towards an improved skin wound healingpt_PT
dc.typejournal article
dspace.entity.typePublication
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oaire.awardNumberPTDC/EBB-BIO/114320/2009
oaire.awardNumberSFRH/BD/80648/2011
oaire.awardNumberSFRH/BD/109563/2015
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes [UID/QUI/50006/2013]
oaire.awardTitleHealth Sciences Research Centre [UID/Multi/00709/2013]
oaire.awardTitleSmart porous particles for pulmonary drug and vaccine delivery [PTDC/EQU-EQU/116097/2009]
oaire.awardTitleIsolation and Purification of Plasmid DNA for Cancer Therapy [PTDC/EBB-BIO/114320/2009]
oaire.awardTitleBolsa de Doutoramento FCT: Development of hydrogels loaded with microparticles containing cells and biomolecules for skin regeneration [SFRH/BD/80648/2011]
oaire.awardTitleBolsa de Doutoramento FCT: Development of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing [SFRH/BD/109563/2015]
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F50006%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FEQU-EQU%2F116097%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FEBB-BIO%2F114320%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F80648%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.citation.endPage145pt_PT
oaire.citation.startPage136pt_PT
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume159pt_PT
oaire.fundingStream6817 - DCRRNI ID
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person.familyNameDa Cruz Morgado Ferreira
person.familyNamePereira Miguel
person.familyNameCorreia
person.familyNameAguiar-Ricardo
person.givenNamePatrícia Isabel
person.givenNameSónia Alexandra
person.givenNameIlídio Joaquim Sobreira
person.givenNameAna
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person.identifier.ciencia-idE71C-3D0E-821B
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person.identifier.ciencia-idF610-7373-DC81
person.identifier.ciencia-id2C1A-9947-19BA
person.identifier.orcid0000-0002-1005-9853
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0003-1613-9675
person.identifier.orcid0000-0002-2193-1440
person.identifier.ridC-3286-2011
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id7003557499
person.identifier.scopus-author-id6602194100
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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project.funder.nameFundação para a Ciência e a Tecnologia
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