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An overview of electrospun membranes loaded with bioactive molecules for improving the wound healing process

2019-03-07Journal article Open access
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dc.contributor.authorMiguel, Sónia
dc.contributor.authorSequeira, Rosa
dc.contributor.authorMoreira, André
dc.contributor.authorCabral, C.S.D.
dc.contributor.authorMendonça, António
dc.contributor.authorFerreira, Paula
dc.contributor.authorCorreia, I.J.
dc.date.accessioned2019-03-12T10:54:29Z
dc.date.available2022-03-08T01:30:16Z
dc.date.issued2019-03-07
dc.description.abstractNowadays, despite the intensive research performed in the area of skin tissue engineering, the treatment of skin lesions remains a big challenge for healthcare professionals. In fact, none of the wound dressings currently used in the clinic is capable of re-establishing all the native features of skin. An ideal wound dressing must confer protection to the wound from external microorganisms, chemical, and physical aggressions, as well as promote the healing process by stimulating the cell adhesion, differentiation, and proliferation. In recent years different types of wound dressings (such as films, hydrocolloids, hydrogels, micro/nano fibers) have been developed. Among them, electrospun nanofibrous membranes due to their intrinsic properties like high surface area-to-volume ratio, porosity and structural similarity with the skin extracellular matrix have been regarded as highly promising for wound dressings applications. Additionally, the nanofibers available in these membranes can act as drug delivery systems, which prompted the incorporation of biomolecules within their structure to prevent skin infections as well as improve the healing process. In this review, examples of different bioactive molecules that have been loaded on polymeric nanofibers are presented, highlighting the antibacterial biomolecules (e.g. antibiotics, silver nanoparticles and natural extracts-derived products) and the molecules capable of enhancing the healing process (e.g. growth factors, vitamins, and anti-inflammatory molecules).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.ejpb.2019.03.010pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.6/6902
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
dc.relationDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
dc.subjectAntimicrobial moleculespt_PT
dc.subjectBiological moleculespt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectElectrospun nanofiberspt_PT
dc.subjectWound dressingpt_PT
dc.titleAn overview of electrospun membranes loaded with bioactive molecules for improving the wound healing processpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of a bioactive nanofibrous membrane loaded with bioactive molecules for wound healing
oaire.awardTitleDevelopment of layer-by-layer polymeric microneedles for localized delivery of therapeutics to cervical cancer
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F00709%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109563%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F109482%2F2015/PT
oaire.citation.conferencePlaceHolandapt_PT
oaire.citation.endPage22pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEuropean Journal of Pharmaceutics and Biopharmaceuticspt_PT
oaire.citation.volume139pt_PT
oaire.fundingStream5876
oaire.fundingStreamPOR_CENTRO
oaire.fundingStreamPOR_CENTRO
person.familyNamePereira Miguel
person.familyNameMoreira
person.familyNameCabral
person.familyNameMendonça
person.familyNameCalvinho
person.familyNameCorreia
person.givenNameSónia Alexandra
person.givenNameAndré Ferreira
person.givenNameCátia Solange Duarte
person.givenNameAntónio
person.givenNamePaula Cristina Nunes Ferreira
person.givenNameIlídio Joaquim Sobreira
person.identifierGX0L2QAAAAJ
person.identifier1161643
person.identifierUMbJ1KMAAAAJ
person.identifier.ciencia-id1A13-ABC0-C32C
person.identifier.ciencia-id4C1E-012B-83CE
person.identifier.ciencia-id8D18-367B-2572
person.identifier.ciencia-id2419-6E20-F958
person.identifier.ciencia-idA119-FFB8-0899
person.identifier.ciencia-idF610-7373-DC81
person.identifier.orcid0000-0001-7274-0399
person.identifier.orcid0000-0002-0604-2506
person.identifier.orcid0000-0002-4247-4816
person.identifier.orcid0000-0001-8069-0440
person.identifier.orcid0000-0003-3393-4427
person.identifier.orcid0000-0003-1613-9675
person.identifier.ridI-3093-2012
person.identifier.scopus-author-id55638166400
person.identifier.scopus-author-id56401521300
person.identifier.scopus-author-id57207108629
person.identifier.scopus-author-id56890866600
person.identifier.scopus-author-id55321888200
person.identifier.scopus-author-id7003557499
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.embargofctOs autores cederam os direitos de autor à editora.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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